| 05 Mar 16 | r01        | North Queensland Cowboys North Queensl | 20 - 14 | Cronulla SharksCronulla Shar |
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| 12 Mar 16 | r02        | Parramatta EelsParramatta Ee | 20 - 16 | North Queensland Cowboys North Queensl |
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| 17 Mar 16 | r03        | North Queensland Cowboys North Queensl | 40 - 0 | Sydney RoostersSydney Rooste |
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| 25 Mar 16 | r04        | Brisbane BroncosBrisbane Bron | 21 - 20 | North Queensland Cowboys North Queensl |
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| 02 Apr 16 | r05        | North Queensland Cowboys North Queensl | 36 - 0 | St. George Illawara DragoSt. George Il |
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| 09 Apr 16 | r06        | Penrith PanthersPenrith Panth | 18 - 23 | North Queensland Cowboys North Queensl |
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| 15 Apr 16 | r07        | North Queensland Cowboys North Queensl | 44 - 18 | South Sydney RabbitohsSouth Sydney |
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| 23 Apr 16 | r08        | North Queensland Cowboys North Queensl | 32 - 16 | Parramatta EelsParramatta Ee |
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| 30 Apr 16 | r09        | Manly Sea EaglesManly Sea Eag | 18 - 34 | North Queensland Cowboys North Queensl |
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| 14 May 16 | r10        | Melbourne StormMelbourne Sto | 15 - 14 | North Queensland Cowboys North Queensl |
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| 20 May 16 | r11        | North Queensland Cowboys North Queensl | 19 - 18 | Brisbane BroncosBrisbane Bron |
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| 28 May 16 | r12        | St. George Illawara DragoSt. George Il | 14 - 10 | North Queensland Cowboys North Queensl |
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| 04 Jun 16 | r13        | North Queensland Cowboys North Queensl | 46 - 16 | Newcastle Knights Newcastle Kni |
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| 13 Jun 16 | r14        | Cronulla SharksCronulla Shar | 13 - 10 | North Queensland Cowboys North Queensl |
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| 27 Jun 16 | r16        | North Queensland Cowboys North Queensl | 30 - 26 | Manly Sea EaglesManly Sea Eag |
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| 03 Jul 16 | r17        | South Sydney RabbitohsSouth Sydney | 0 - 20 | North Queensland Cowboys North Queensl |
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| 11 Jul 16 | r18        | Canberra RaidersCanberra Raid | 26 - 12 | North Queensland Cowboys North Queensl |
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| 21 Jul 16 | r20        | North Queensland Cowboys North Queensl | 36 - 0 | Canterbury Bankstown BullCanterbury Ba |
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| 30 Jul 16 | r21        | North Queensland Cowboys North Queensl | 8 - 16 | Melbourne StormMelbourne Sto |
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| 07 Aug 16 | r22        | Wests TigersWests Tigers | 26 - 14 | North Queensland Cowboys North Queensl |
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| 14 Aug 16 | r23        | Sydney RoostersSydney Rooste | 22 - 10 | North Queensland Cowboys North Queensl |
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| 20 Aug 16 | r24        | North Queensland Cowboys North Queensl | 34 - 6 | New Zealand WarriorsNew Zealand W |
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| 25 Aug 16 | r25        | Canterbury Bankstown BullCanterbury Ba | 16 - 24 | North Queensland Cowboys North Queensl |
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| 03 Sep 16 | r26        | North Queensland Cowboys North Queensl | 32 - 16 | Gold Coast TitansGold Coast Ti |
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| 10 Sep 16 | r00        | Melbourne StormMelbourne Sto | 16 - 10 | North Queensland Cowboys North Queensl |
| 16 Sep 16 | r00        | North Queensland Cowboys North Queensl | 26 - 20 | Brisbane BroncosBrisbane Bron |
| 23 Sep 16 | r00        | Cronulla SharksCronulla Shar | 32 - 20 | North Queensland Cowboys North Queensl |