| 13 Mar 10 | r01        | Canterbury Bankstown BullCanterbury Ba | 16 - 20 | Newcastle Knights Newcastle Kni |
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| 20 Mar 10 | r02        | Newcastle Knights Newcastle Kni | 14 - 20 | Melbourne StormMelbourne Sto |
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| 27 Mar 10 | r03        | Manly Sea EaglesManly Sea Eag | 36 - 12 | Newcastle Knights Newcastle Kni |
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| 05 Apr 10 | r04        | Newcastle Knights Newcastle Kni | 30 - 34 | Penrith PanthersPenrith Panth |
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| 10 Apr 10 | r05        | South Sydney RabbitohsSouth Sydney | 28 - 10 | Newcastle Knights Newcastle Kni |
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| 17 Apr 10 | r06        | Newcastle Knights Newcastle Kni | 36 - 18 | North Queensland Cowboys North Queensl |
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| 24 Apr 10 | r07        | Cronulla SharksCronulla Shar | 26 - 6 | Newcastle Knights Newcastle Kni |
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| 30 Apr 10 | r08        | Brisbane BroncosBrisbane Bron | 22 - 30 | Newcastle Knights Newcastle Kni |
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| 09 May 10 | r09        | Newcastle Knights Newcastle Kni | 36 - 38 | Gold Coast TitansGold Coast Ti |
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| 15 May 10 | r10        | Sydney RoostersSydney Rooste | 18 - 34 | Newcastle Knights Newcastle Kni |
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| 21 May 10 | r11        | Newcastle Knights Newcastle Kni | 6 - 23 | Wests TigersWests Tigers |
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| 05 Jun 10 | r13        | Penrith PanthersPenrith Panth | 28 - 10 | Newcastle Knights Newcastle Kni |
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| 13 Jun 10 | r14        | Newcastle Knights Newcastle Kni | 24 - 32 | New Zealand WarriorsNew Zealand W |
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| 21 Jun 10 | r15        | Newcastle Knights Newcastle Kni | 6 - 4 | Parramatta EelsParramatta Ee |
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| 27 Jun 10 | r16        | Gold Coast TitansGold Coast Ti | 16 - 24 | Newcastle Knights Newcastle Kni |
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| 11 Jul 10 | r18        | Newcastle Knights Newcastle Kni | 21 - 10 | Cronulla SharksCronulla Shar |
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| 18 Jul 10 | r19        | Canberra RaidersCanberra Raid | 52 - 18 | Newcastle Knights Newcastle Kni |
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| 24 Jul 10 | r20        | North Queensland Cowboys North Queensl | 28 - 24 | Newcastle Knights Newcastle Kni |
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| 02 Aug 10 | r21        | Newcastle Knights Newcastle Kni | 32 - 14 | Manly Sea EaglesManly Sea Eag |
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| 08 Aug 10 | r22        | Newcastle Knights Newcastle Kni | 30 - 6 | Canterbury Bankstown BullCanterbury Ba |
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| 15 Aug 10 | r23        | New Zealand WarriorsNew Zealand W | 22 - 10 | Newcastle Knights Newcastle Kni |
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| 20 Aug 10 | r24        | Newcastle Knights Newcastle Kni | 44 - 18 | Brisbane BroncosBrisbane Bron |
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| 28 Aug 10 | r25        | Newcastle Knights Newcastle Kni | 18 - 26 | St. George Illawara DragoSt. George Il |
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| 05 Sep 10 | r26        | Melbourne StormMelbourne Sto | 34 - 4 | Newcastle Knights Newcastle Kni |