| 13 Mar 10 | r01        | Penrith PanthersPenrith Panth | 34 - 16 | Canberra RaidersCanberra Raid |
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| 20 Mar 10 | r02        | North Queensland Cowboys North Queensl | 28 - 20 | Penrith PanthersPenrith Panth |
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| 27 Mar 10 | r03        | Penrith PanthersPenrith Panth | 10 - 16 | Melbourne StormMelbourne Sto |
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| 05 Apr 10 | r04        | Newcastle Knights Newcastle Kni | 30 - 34 | Penrith PanthersPenrith Panth |
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| 11 Apr 10 | r05        | Penrith PanthersPenrith Panth | 28 - 6 | Sydney RoostersSydney Rooste |
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| 18 Apr 10 | r06        | New Zealand WarriorsNew Zealand W | 12 - 40 | Penrith PanthersPenrith Panth |
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| 24 Apr 10 | r07        | Penrith PanthersPenrith Panth | 26 - 18 | Wests TigersWests Tigers |
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| 01 May 10 | r08        | Gold Coast TitansGold Coast Ti | 38 - 24 | Penrith PanthersPenrith Panth |
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| 16 May 10 | r10        | Cronulla SharksCronulla Shar | 14 - 34 | Penrith PanthersPenrith Panth |
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| 24 May 10 | r11        | Penrith PanthersPenrith Panth | 31 - 16 | Canterbury Bankstown BullCanterbury Ba |
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| 30 May 10 | r12        | South Sydney RabbitohsSouth Sydney | 42 - 22 | Penrith PanthersPenrith Panth |
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| 05 Jun 10 | r13        | Penrith PanthersPenrith Panth | 28 - 10 | Newcastle Knights Newcastle Kni |
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| 18 Jun 10 | r15        | Brisbane BroncosBrisbane Bron | 12 - 22 | Penrith PanthersPenrith Panth |
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| 25 Jun 10 | r16        | Penrith PanthersPenrith Panth | 40 - 22 | Manly Sea EaglesManly Sea Eag |
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| 05 Jul 10 | r17        | St. George Illawara DragoSt. George Il | 8 - 12 | Penrith PanthersPenrith Panth |
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| 11 Jul 10 | r18        | Penrith PanthersPenrith Panth | 6 - 12 | New Zealand WarriorsNew Zealand W |
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| 17 Jul 10 | r19        | Penrith PanthersPenrith Panth | 28 - 34 | Parramatta EelsParramatta Ee |
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| 24 Jul 10 | r20        | Melbourne StormMelbourne Sto | 18 - 10 | Penrith PanthersPenrith Panth |
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| 30 Jul 10 | r21        | Penrith PanthersPenrith Panth | 24 - 16 | North Queensland Cowboys North Queensl |
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| 09 Aug 10 | r22        | Canberra RaidersCanberra Raid | 30 - 26 | Penrith PanthersPenrith Panth |
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| 15 Aug 10 | r23        | Wests TigersWests Tigers | 43 - 18 | Penrith PanthersPenrith Panth |
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| 20 Aug 10 | r24        | Penrith PanthersPenrith Panth | 54 - 18 | South Sydney RabbitohsSouth Sydney |
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| 30 Aug 10 | r25        | Canterbury Bankstown BullCanterbury Ba | 18 - 24 | Penrith PanthersPenrith Panth |
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| 04 Sep 10 | r26        | Penrith PanthersPenrith Panth | 50 - 12 | Cronulla SharksCronulla Shar |
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| 11 Sep 10 | r00        | Penrith PanthersPenrith Panth | 22 - 24 | Canberra RaidersCanberra Raid |
| 18 Sep 10 | r00        | Sydney RoostersSydney Rooste | 34 - 12 | Penrith PanthersPenrith Panth |