| 12 Mar 10 | r01        | Brisbane BroncosBrisbane Bron | 30 - 24 | North Queensland Cowboys North Queensl |
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| 22 Mar 10 | r02        | Canberra RaidersCanberra Raid | 22 - 14 | Brisbane BroncosBrisbane Bron |
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| 28 Mar 10 | r03        | Brisbane BroncosBrisbane Bron | 16 - 48 | New Zealand WarriorsNew Zealand W |
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| 02 Apr 10 | r04        | Sydney RoostersSydney Rooste | 25 - 6 | Brisbane BroncosBrisbane Bron |
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| 09 Apr 10 | r05        | St. George Illawara DragoSt. George Il | 34 - 16 | Brisbane BroncosBrisbane Bron |
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| 18 Apr 10 | r06        | Brisbane BroncosBrisbane Bron | 44 - 16 | Cronulla SharksCronulla Shar |
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| 23 Apr 10 | r07        | Canterbury Bankstown BullCanterbury Ba | 36 - 18 | Brisbane BroncosBrisbane Bron |
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| 30 Apr 10 | r08        | Brisbane BroncosBrisbane Bron | 22 - 30 | Newcastle Knights Newcastle Kni |
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| 09 May 10 | r09        | Melbourne StormMelbourne Sto | 14 - 36 | Brisbane BroncosBrisbane Bron |
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| 14 May 10 | r10        | Brisbane BroncosBrisbane Bron | 28 - 6 | Gold Coast TitansGold Coast Ti |
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| 29 May 10 | r12        | Cronulla SharksCronulla Shar | 4 - 20 | Brisbane BroncosBrisbane Bron |
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| 06 Jun 10 | r13        | Manly Sea EaglesManly Sea Eag | 6 - 22 | Brisbane BroncosBrisbane Bron |
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| 13 Jun 10 | r14        | Brisbane BroncosBrisbane Bron | 50 - 22 | South Sydney RabbitohsSouth Sydney |
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| 18 Jun 10 | r15        | Brisbane BroncosBrisbane Bron | 12 - 22 | Penrith PanthersPenrith Panth |
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| 26 Jun 10 | r16        | Parramatta EelsParramatta Ee | 6 - 10 | Brisbane BroncosBrisbane Bron |
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| 02 Jul 10 | r17        | Brisbane BroncosBrisbane Bron | 14 - 16 | Wests TigersWests Tigers |
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| 16 Jul 10 | r19        | Gold Coast TitansGold Coast Ti | 10 - 24 | Brisbane BroncosBrisbane Bron |
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| 26 Jul 10 | r20        | Brisbane BroncosBrisbane Bron | 30 - 34 | Sydney RoostersSydney Rooste |
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| 01 Aug 10 | r21        | Brisbane BroncosBrisbane Bron | 10 - 6 | St. George Illawara DragoSt. George Il |
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| 06 Aug 10 | r22        | North Queensland Cowboys North Queensl | 26 - 34 | Brisbane BroncosBrisbane Bron |
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| 13 Aug 10 | r23        | Brisbane BroncosBrisbane Bron | 14 - 30 | Parramatta EelsParramatta Ee |
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| 20 Aug 10 | r24        | Newcastle Knights Newcastle Kni | 44 - 18 | Brisbane BroncosBrisbane Bron |
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| 27 Aug 10 | r25        | New Zealand WarriorsNew Zealand W | 36 - 4 | Brisbane BroncosBrisbane Bron |
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| 03 Sep 10 | r26        | Brisbane BroncosBrisbane Bron | 16 - 18 | Canberra RaidersCanberra Raid |