| 13 Aug 21 | r01        | HuescaHuesca | 2 - 0 | EibarEibar |
| 13 Aug 21 | r01        | ZaragozaZaragoza | 0 - 0 | UD IbizaUD Ibiza |
| 14 Aug 21 | r01        | Real Sociedad BReal Sociedad | 1 - 0 | LeganesLeganes |
| 14 Aug 21 | r01        | GironaGirona | 2 - 0 | SD AmorebietaSD Amorebieta |
| 14 Aug 21 | r01        | PonferradinaPonferradina | 1 - 0 | AlcorconAlcorcon |
| 15 Aug 21 | r01        | Sp GijonSp Gijon | 1 - 0 | BurgosBurgos |
| 15 Aug 21 | r01        | Real OviedoReal Oviedo | 2 - 2 | LugoLugo |
| 15 Aug 21 | r01        | Las PalmasLas Palmas | 1 - 1 | ValladolidValladolid |
| 15 Aug 21 | r01        | FuenlabradaFuenlabrada | 1 - 2 | TenerifeTenerife |
| 16 Aug 21 | r01        | MalagaMalaga | 0 - 0 | MirandesMirandes |
| 16 Aug 21 | r01        | Cartagena FCCartagena FC | 1 - 3 | AlmeriaAlmeria |
| |
| 20 Aug 21 | r02        | ValladolidValladolid | 2 - 0 | ZaragozaZaragoza |
| 20 Aug 21 | r02        | AlmeriaAlmeria | 2 - 1 | Real OviedoReal Oviedo |
| 21 Aug 21 | r02        | LugoLugo | 0 - 0 | Real Sociedad BReal Sociedad |
| 21 Aug 21 | r02        | TenerifeTenerife | 0 - 0 | Sp GijonSp Gijon |
| 21 Aug 21 | r02        | AlcorconAlcorcon | 0 - 2 | FuenlabradaFuenlabrada |
| 22 Aug 21 | r02        | UD IbizaUD Ibiza | 2 - 2 | MalagaMalaga |
| 22 Aug 21 | r02        | EibarEibar | 0 - 1 | PonferradinaPonferradina |
| 22 Aug 21 | r02        | GironaGirona | 0 - 0 | Las PalmasLas Palmas |
| 22 Aug 21 | r02        | HuescaHuesca | 2 - 0 | Cartagena FCCartagena FC |
| 23 Aug 21 | r02        | MirandesMirandes | 2 - 0 | SD AmorebietaSD Amorebieta |
| 23 Aug 21 | r02        | LeganesLeganes | 0 - 0 | BurgosBurgos |
| |
| 27 Aug 21 | r03        | Las PalmasLas Palmas | 2 - 1 | HuescaHuesca |
| 27 Aug 21 | r03        | MalagaMalaga | 1 - 0 | AlcorconAlcorcon |
| 28 Aug 21 | r03        | Sp GijonSp Gijon | 2 - 1 | MirandesMirandes |
| 28 Aug 21 | r03        | LeganesLeganes | 1 - 2 | UD IbizaUD Ibiza |
| 28 Aug 21 | r03        | Real OviedoReal Oviedo | 0 - 0 | TenerifeTenerife |
| 28 Aug 21 | r03        | PonferradinaPonferradina | 2 - 1 | GironaGirona |
| 29 Aug 21 | r03        | SD AmorebietaSD Amorebieta | 2 - 1 | AlmeriaAlmeria |
| 29 Aug 21 | r03        | LugoLugo | 0 - 2 | ValladolidValladolid |
| 29 Aug 21 | r03        | Real Sociedad BReal Sociedad | 0 - 0 | FuenlabradaFuenlabrada |
| 29 Aug 21 | r03        | BurgosBurgos | 0 - 1 | EibarEibar |
| 30 Aug 21 | r03        | ZaragozaZaragoza | 0 - 1 | Cartagena FCCartagena FC |
| |
| 03 Sep 21 | r04        | GironaGirona | 1 - 2 | Sp GijonSp Gijon |
| 04 Sep 21 | r04        | EibarEibar | 1 - 1 | LeganesLeganes |
| 04 Sep 21 | r04        | Cartagena FCCartagena FC | 1 - 0 | Real Sociedad BReal Sociedad |
| 04 Sep 21 | r04        | TenerifeTenerife | 2 - 0 | PonferradinaPonferradina |
| 04 Sep 21 | r04        | AlmeriaAlmeria | 2 - 0 | MalagaMalaga |
| 04 Sep 21 | r04        | FuenlabradaFuenlabrada | 1 - 1 | LugoLugo |
| 05 Sep 21 | r04        | BurgosBurgos | 3 - 0 | ValladolidValladolid |
| 05 Sep 21 | r04        | UD IbizaUD Ibiza | 1 - 1 | SD AmorebietaSD Amorebieta |
| 05 Sep 21 | r04        | MirandesMirandes | 4 - 2 | Las PalmasLas Palmas |
| 05 Sep 21 | r04        | AlcorconAlcorcon | 1 - 2 | ZaragozaZaragoza |
| 06 Sep 21 | r04        | HuescaHuesca | 1 - 2 | Real OviedoReal Oviedo |
| |
| 10 Sep 21 | r05        | Sp GijonSp Gijon | 2 - 1 | LeganesLeganes |
| 11 Sep 21 | r05        | SD AmorebietaSD Amorebieta | 2 - 2 | BurgosBurgos |
| 11 Sep 21 | r05        | Real Sociedad BReal Sociedad | 2 - 3 | EibarEibar |
| 11 Sep 21 | r05        | Las PalmasLas Palmas | 1 - 1 | UD IbizaUD Ibiza |
| 11 Sep 21 | r05        | MirandesMirandes | 1 - 3 | AlcorconAlcorcon |
| 12 Sep 21 | r05        | Real OviedoReal Oviedo | 2 - 0 | Cartagena FCCartagena FC |
| 12 Sep 21 | r05        | ValladolidValladolid | 0 - 2 | TenerifeTenerife |
| 12 Sep 21 | r05        | PonferradinaPonferradina | 1 - 0 | AlmeriaAlmeria |
| 12 Sep 21 | r05        | FuenlabradaFuenlabrada | 1 - 1 | ZaragozaZaragoza |
| 12 Sep 21 | r05        | MalagaMalaga | 2 - 0 | GironaGirona |
| 13 Sep 21 | r05        | LugoLugo | 3 - 2 | HuescaHuesca |
| |
| 17 Sep 21 | r06        | AlcorconAlcorcon | 0 - 4 | AlmeriaAlmeria |
| 18 Sep 21 | r06        | UD IbizaUD Ibiza | 1 - 1 | Real OviedoReal Oviedo |
| 18 Sep 21 | r06        | LeganesLeganes | 1 - 0 | SD AmorebietaSD Amorebieta |
| 18 Sep 21 | r06        | ZaragozaZaragoza | 1 - 1 | Real Sociedad BReal Sociedad |
| 18 Sep 21 | r06        | GironaGirona | 1 - 0 | ValladolidValladolid |
| 18 Sep 21 | r06        | Cartagena FCCartagena FC | 2 - 1 | LugoLugo |
| 19 Sep 21 | r06        | HuescaHuesca | 0 - 0 | FuenlabradaFuenlabrada |
| 19 Sep 21 | r06        | PonferradinaPonferradina | 4 - 0 | MalagaMalaga |
| 19 Sep 21 | r06        | EibarEibar | 3 - 2 | Sp GijonSp Gijon |
| 19 Sep 21 | r06        | TenerifeTenerife | 1 - 2 | MirandesMirandes |
| 20 Sep 21 | r06        | BurgosBurgos | 0 - 0 | Las PalmasLas Palmas |
| |
| 24 Sep 21 | r07        | Real Sociedad BReal Sociedad | 0 - 2 | HuescaHuesca |
| 24 Sep 21 | r07        | AlmeriaAlmeria | 3 - 1 | TenerifeTenerife |
| 25 Sep 21 | r07        | UD IbizaUD Ibiza | 2 - 0 | BurgosBurgos |
| 25 Sep 21 | r07        | Las PalmasLas Palmas | 2 - 1 | PonferradinaPonferradina |
| 25 Sep 21 | r07        | SD AmorebietaSD Amorebieta | 1 - 1 | EibarEibar |
| 26 Sep 21 | r07        | MirandesMirandes | 1 - 2 | LeganesLeganes |
| 26 Sep 21 | r07        | Sp GijonSp Gijon | 2 - 1 | MalagaMalaga |
| 26 Sep 21 | r07        | Real OviedoReal Oviedo | 0 - 0 | GironaGirona |
| 26 Sep 21 | r07        | LugoLugo | 1 - 1 | ZaragozaZaragoza |
| 26 Sep 21 | r07        | ValladolidValladolid | 2 - 0 | AlcorconAlcorcon |
| 27 Sep 21 | r07        | FuenlabradaFuenlabrada | 2 - 1 | Cartagena FCCartagena FC |
| |
| 01 Oct 21 | r08        | PonferradinaPonferradina | 2 - 2 | ValladolidValladolid |
| 02 Oct 21 | r08        | HuescaHuesca | 1 - 2 | TenerifeTenerife |
| 02 Oct 21 | r08        | SD AmorebietaSD Amorebieta | 1 - 1 | Sp GijonSp Gijon |
| 02 Oct 21 | r08        | ZaragozaZaragoza | 0 - 0 | Real OviedoReal Oviedo |
| 02 Oct 21 | r08        | AlcorconAlcorcon | 1 - 4 | Real Sociedad BReal Sociedad |
| 03 Oct 21 | r08        | EibarEibar | 3 - 1 | UD IbizaUD Ibiza |
| 03 Oct 21 | r08        | MalagaMalaga | 1 - 0 | FuenlabradaFuenlabrada |
| 03 Oct 21 | r08        | BurgosBurgos | 1 - 0 | MirandesMirandes |
| 03 Oct 21 | r08        | Las PalmasLas Palmas | 4 - 1 | Cartagena FCCartagena FC |
| 03 Oct 21 | r08        | LeganesLeganes | 1 - 1 | LugoLugo |
| 04 Oct 21 | r08        | GironaGirona | 1 - 2 | AlmeriaAlmeria |
| |
| 08 Oct 21 | r09        | ValladolidValladolid | 1 - 1 | MalagaMalaga |
| 09 Oct 21 | r09        | LugoLugo | 1 - 0 | GironaGirona |
| 09 Oct 21 | r09        | MirandesMirandes | 3 - 3 | EibarEibar |
| 09 Oct 21 | r09        | AlmeriaAlmeria | 1 - 1 | Las PalmasLas Palmas |
| 09 Oct 21 | r09        | Real OviedoReal Oviedo | 1 - 1 | Sp GijonSp Gijon |
| 10 Oct 21 | r09        | Real Sociedad BReal Sociedad | 1 - 1 | PonferradinaPonferradina |
| 10 Oct 21 | r09        | Cartagena FCCartagena FC | 5 - 1 | UD IbizaUD Ibiza |
| 10 Oct 21 | r09        | FuenlabradaFuenlabrada | 2 - 1 | LeganesLeganes |
| 10 Oct 21 | r09        | TenerifeTenerife | 2 - 1 | SD AmorebietaSD Amorebieta |
| 10 Oct 21 | r09        | AlcorconAlcorcon | 1 - 0 | BurgosBurgos |
| 11 Oct 21 | r09        | ZaragozaZaragoza | 0 - 0 | HuescaHuesca |
| |
| 15 Oct 21 | r10        | EibarEibar | 1 - 0 | AlmeriaAlmeria |