| 23 Jul 21 | r01        | Schalke 04Schalke 04 | 1 - 3 | HamburgHamburg |
| 24 Jul 21 | r01        | DarmstadtDarmstadt | 0 - 2 | Jahn RegensburgJahn Regensbu |
| 24 Jul 21 | r01        | FC HeidenheimFC Heidenheim | 0 - 0 | PaderbornPaderborn |
| 24 Jul 21 | r01        | Dynamo DresdenDynamo Dresde | 3 - 0 | IngolstadtIngolstadt |
| 24 Jul 21 | r01        | Hansa RostockHansa Rostock | 1 - 3 | KarlsruheKarlsruhe |
| 24 Jul 21 | r01        | Werder BremenWerder Bremen | 1 - 1 | HannoverHannover |
| 25 Jul 21 | r01        | SandhausenSandhausen | 0 - 2 | Fortuna DüsseldorfFortuna Düsse |
| 25 Jul 21 | r01        | St PauliSt Pauli | 3 - 0 | Holstein KielHolstein Kiel |
| 25 Jul 21 | r01        | NurnbergNurnberg | 0 - 0 | AueAue |
| |
| 30 Jul 21 | r02        | KarlsruheKarlsruhe | 3 - 0 | DarmstadtDarmstadt |
| 30 Jul 21 | r02        | PaderbornPaderborn | 2 - 2 | NurnbergNurnberg |
| 31 Jul 21 | r02        | HannoverHannover | 0 - 3 | Hansa RostockHansa Rostock |
| 31 Jul 21 | r02        | Jahn RegensburgJahn Regensbu | 3 - 0 | SandhausenSandhausen |
| 31 Jul 21 | r02        | IngolstadtIngolstadt | 1 - 2 | FC HeidenheimFC Heidenheim |
| 31 Jul 21 | r02        | Fortuna DüsseldorfFortuna Düsse | 2 - 3 | Werder BremenWerder Bremen |
| 01 Aug 21 | r02        | Holstein KielHolstein Kiel | 0 - 3 | Schalke 04Schalke 04 |
| 01 Aug 21 | r02        | HamburgHamburg | 1 - 1 | Dynamo DresdenDynamo Dresde |
| 01 Aug 21 | r02        | AueAue | 0 - 0 | St PauliSt Pauli |
| |
| 13 Aug 21 | r03        | Schalke 04Schalke 04 | 1 - 1 | AueAue |
| 13 Aug 21 | r03        | St PauliSt Pauli | 3 - 2 | HamburgHamburg |
| 14 Aug 21 | r03        | SandhausenSandhausen | 0 - 0 | KarlsruheKarlsruhe |
| 14 Aug 21 | r03        | Holstein KielHolstein Kiel | 0 - 3 | Jahn RegensburgJahn Regensbu |
| 14 Aug 21 | r03        | NurnbergNurnberg | 2 - 0 | Fortuna DüsseldorfFortuna Düsse |
| 14 Aug 21 | r03        | Dynamo DresdenDynamo Dresde | 2 - 0 | HannoverHannover |
| 15 Aug 21 | r03        | Werder BremenWerder Bremen | 1 - 4 | PaderbornPaderborn |
| 15 Aug 21 | r03        | DarmstadtDarmstadt | 6 - 1 | IngolstadtIngolstadt |
| 15 Aug 21 | r03        | FC HeidenheimFC Heidenheim | 1 - 1 | Hansa RostockHansa Rostock |
| |
| 20 Aug 21 | r04        | Fortuna DüsseldorfFortuna Düsse | 2 - 2 | Holstein KielHolstein Kiel |
| 20 Aug 21 | r04        | HannoverHannover | 1 - 0 | FC HeidenheimFC Heidenheim |
| 21 Aug 21 | r04        | KarlsruheKarlsruhe | 0 - 0 | Werder BremenWerder Bremen |
| 21 Aug 21 | r04        | PaderbornPaderborn | 3 - 1 | St PauliSt Pauli |
| 21 Aug 21 | r04        | Jahn RegensburgJahn Regensbu | 4 - 1 | Schalke 04Schalke 04 |
| 21 Aug 21 | r04        | Hansa RostockHansa Rostock | 1 - 3 | Dynamo DresdenDynamo Dresde |
| 22 Aug 21 | r04        | HamburgHamburg | 2 - 2 | DarmstadtDarmstadt |
| 22 Aug 21 | r04        | AueAue | 1 - 3 | SandhausenSandhausen |
| 22 Aug 21 | r04        | IngolstadtIngolstadt | 0 - 0 | NurnbergNurnberg |
| |
| 27 Aug 21 | r05        | SandhausenSandhausen | 0 - 2 | IngolstadtIngolstadt |
| 27 Aug 21 | r05        | NurnbergNurnberg | 2 - 1 | KarlsruheKarlsruhe |
| 28 Aug 21 | r05        | Holstein KielHolstein Kiel | 3 - 0 | AueAue |
| 28 Aug 21 | r05        | DarmstadtDarmstadt | 4 - 0 | HannoverHannover |
| 28 Aug 21 | r05        | FC HeidenheimFC Heidenheim | 0 - 0 | HamburgHamburg |
| 28 Aug 21 | r05        | Schalke 04Schalke 04 | 3 - 1 | Fortuna DüsseldorfFortuna Düsse |
| 29 Aug 21 | r05        | Werder BremenWerder Bremen | 3 - 0 | Hansa RostockHansa Rostock |
| 29 Aug 21 | r05        | St PauliSt Pauli | 2 - 0 | Jahn RegensburgJahn Regensbu |
| 29 Aug 21 | r05        | Dynamo DresdenDynamo Dresde | 0 - 3 | PaderbornPaderborn |
| |
| 11 Sep 21 | r06        | KarlsruheKarlsruhe | 2 - 2 | Holstein KielHolstein Kiel |
| 11 Sep 21 | r06        | HannoverHannover | 1 - 0 | St PauliSt Pauli |
| 11 Sep 21 | r06        | IngolstadtIngolstadt | 0 - 3 | Werder BremenWerder Bremen |
| 11 Sep 21 | r06        | HamburgHamburg | 2 - 1 | SandhausenSandhausen |
| 12 Sep 21 | r06        | FC HeidenheimFC Heidenheim | 2 - 1 | Dynamo DresdenDynamo Dresde |
| 12 Sep 21 | r06        | PaderbornPaderborn | 0 - 1 | Schalke 04Schalke 04 |
| 12 Sep 21 | r06        | AueAue | 0 - 1 | Fortuna DüsseldorfFortuna Düsse |
| 12 Sep 21 | r06        | Jahn RegensburgJahn Regensbu | 2 - 2 | NurnbergNurnberg |
| 12 Sep 21 | r06        | Hansa RostockHansa Rostock | 2 - 1 | DarmstadtDarmstadt |
| |
| 17 Sep 21 | r07        | Schalke 04Schalke 04 | 1 - 2 | KarlsruheKarlsruhe |
| 17 Sep 21 | r07        | NurnbergNurnberg | 1 - 0 | Hansa RostockHansa Rostock |
| 18 Sep 21 | r07        | SandhausenSandhausen | 1 - 3 | FC HeidenheimFC Heidenheim |
| 18 Sep 21 | r07        | Holstein KielHolstein Kiel | 0 - 3 | HannoverHannover |
| 18 Sep 21 | r07        | Fortuna DüsseldorfFortuna Düsse | 1 - 1 | Jahn RegensburgJahn Regensbu |
| 18 Sep 21 | r07        | Werder BremenWerder Bremen | 0 - 2 | HamburgHamburg |
| 19 Sep 21 | r07        | DarmstadtDarmstadt | 1 - 0 | Dynamo DresdenDynamo Dresde |
| 19 Sep 21 | r07        | St PauliSt Pauli | 4 - 1 | IngolstadtIngolstadt |
| 19 Sep 21 | r07        | AueAue | 1 - 4 | PaderbornPaderborn |
| |
| 24 Sep 21 | r08        | FC HeidenheimFC Heidenheim | 2 - 1 | DarmstadtDarmstadt |
| 24 Sep 21 | r08        | Jahn RegensburgJahn Regensbu | 3 - 2 | AueAue |
| 25 Sep 21 | r08        | KarlsruheKarlsruhe | 1 - 3 | St PauliSt Pauli |
| 25 Sep 21 | r08        | PaderbornPaderborn | 1 - 2 | Holstein KielHolstein Kiel |
| 25 Sep 21 | r08        | IngolstadtIngolstadt | 1 - 2 | Fortuna DüsseldorfFortuna Düsse |
| 25 Sep 21 | r08        | Hansa RostockHansa Rostock | 0 - 2 | Schalke 04Schalke 04 |
| 26 Sep 21 | r08        | HamburgHamburg | 2 - 2 | NurnbergNurnberg |
| 26 Sep 21 | r08        | HannoverHannover | 1 - 2 | SandhausenSandhausen |
| 26 Sep 21 | r08        | Dynamo DresdenDynamo Dresde | 3 - 0 | Werder BremenWerder Bremen |
| |
| 01 Oct 21 | r09        | Werder BremenWerder Bremen | 3 - 0 | FC HeidenheimFC Heidenheim |
| 01 Oct 21 | r09        | AueAue | 1 - 1 | HamburgHamburg |
| 02 Oct 21 | r09        | Holstein KielHolstein Kiel | 0 - 2 | Hansa RostockHansa Rostock |
| 02 Oct 21 | r09        | Fortuna DüsseldorfFortuna Düsse | 2 - 3 | PaderbornPaderborn |
| 02 Oct 21 | r09        | Jahn RegensburgJahn Regensbu | 2 - 2 | KarlsruheKarlsruhe |
| 02 Oct 21 | r09        | NurnbergNurnberg | 0 - 0 | HannoverHannover |
| 03 Oct 21 | r09        | SandhausenSandhausen | 1 - 6 | DarmstadtDarmstadt |
| 03 Oct 21 | r09        | Schalke 04Schalke 04 | 3 - 0 | IngolstadtIngolstadt |
| 03 Oct 21 | r09        | St PauliSt Pauli | 3 - 0 | Dynamo DresdenDynamo Dresde |
| |
| 15 Oct 21 | r10        | PaderbornPaderborn | 1 - 1 | Jahn RegensburgJahn Regensbu |
| 15 Oct 21 | r10        | HannoverHannover | 0 - 1 | Schalke 04Schalke 04 |
| 16 Oct 21 | r10        | KarlsruheKarlsruhe | 2 - 1 | AueAue |
| 16 Oct 21 | r10        | FC HeidenheimFC Heidenheim | 2 - 4 | St PauliSt Pauli |
| 16 Oct 21 | r10        | IngolstadtIngolstadt | 1 - 1 | Holstein KielHolstein Kiel |
| 16 Oct 21 | r10        | HamburgHamburg | 1 - 1 | Fortuna DüsseldorfFortuna Düsse |
| 17 Oct 21 | r10        | DarmstadtDarmstadt | 3 - 0 | Werder BremenWerder Bremen |
| 17 Oct 21 | r10        | Dynamo DresdenDynamo Dresde | 0 - 1 | NurnbergNurnberg |
| 17 Oct 21 | r10        | Hansa RostockHansa Rostock | 1 - 1 | SandhausenSandhausen |
| |
| 22 Oct 21 | r11        | PaderbornPaderborn | 1 - 2 | HamburgHamburg |
| 22 Oct 21 | r11        | AueAue | 1 - 0 | IngolstadtIngolstadt |
| 23 Oct 21 | r11        | Holstein KielHolstein Kiel | 1 - 1 | DarmstadtDarmstadt |
| 23 Oct 21 | r11        | Fortuna DüsseldorfFortuna Düsse | 3 - 1 | KarlsruheKarlsruhe |
| 23 Oct 21 | r11        | NurnbergNurnberg | 4 - 0 | FC HeidenheimFC Heidenheim |
| 23 Oct 21 | r11        | Schalke 04Schalke 04 | 3 - 0 | Dynamo DresdenDynamo Dresde |
| 24 Oct 21 | r11        | SandhausenSandhausen | 2 - 2 | Werder BremenWerder Bremen |
| 24 Oct 21 | r11        | St PauliSt Pauli | 4 - 0 | Hansa RostockHansa Rostock |
| 24 Oct 21 | r11        | Jahn RegensburgJahn Regensbu | 3 - 1 | HannoverHannover |
| |
| 29 Oct 21 | r12        | DarmstadtDarmstadt | 2 - 0 | NurnbergNurnberg |