| 07 Aug 21 | r01        | DoncasterDoncaster | 1 - 2 | AFC WimbledonAFC Wimbledon |
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| 14 Aug 21 | r02        | AFC WimbledonAFC Wimbledon | 3 - 3 | BoltonBolton |
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| 17 Aug 21 | r03        | AFC WimbledonAFC Wimbledon | 1 - 1 | GillinghamGillingham |
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| 21 Aug 21 | r04        | SunderlandSunderland | 1 - 0 | AFC WimbledonAFC Wimbledon |
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| 28 Aug 21 | r05        | IpswichIpswich | 2 - 2 | AFC WimbledonAFC Wimbledon |
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| 04 Sep 21 | r06        | AFC WimbledonAFC Wimbledon | 3 - 1 | Oxford UtdOxford Utd |
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| 11 Sep 21 | r07        | MorecambeMorecambe | 3 - 4 | AFC WimbledonAFC Wimbledon |
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| 18 Sep 21 | r08        | AFC WimbledonAFC Wimbledon | 0 - 1 | PlymouthPlymouth |
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| 25 Sep 21 | r09        | ShrewsburyShrewsbury | 2 - 1 | AFC WimbledonAFC Wimbledon |
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| 28 Sep 21 | r10        | RotherhamRotherham | 3 - 0 | AFC WimbledonAFC Wimbledon |
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| 02 Oct 21 | r11        | AFC WimbledonAFC Wimbledon | 1 - 1 | BurtonBurton |
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| 16 Oct 21 | r13        | AFC WimbledonAFC Wimbledon | 2 - 2 | Sheffield WedsSheffield Wed |
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| 19 Oct 21 | r14        | LincolnLincoln | 0 - 1 | AFC WimbledonAFC Wimbledon |
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| 23 Oct 21 | r15        | AFC WimbledonAFC Wimbledon | 0 - 2 | WiganWigan |
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| 30 Oct 21 | r16        | Cambridge UnitedCambridge Uni | 1 - 0 | AFC WimbledonAFC Wimbledon |
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| 20 Nov 21 | r18        | PortsmouthPortsmouth | 2 - 1 | AFC WimbledonAFC Wimbledon |
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| 23 Nov 21 | r19        | AFC WimbledonAFC Wimbledon | 3 - 2 | CreweCrewe |
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| 27 Nov 21 | r20        | AFC WimbledonAFC Wimbledon | 2 - 2 | Fleetwood TownFleetwood Tow |
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| 07 Dec 21 | r21        | AccringtonAccrington | 0 - 2 | AFC WimbledonAFC Wimbledon |
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| 11 Dec 21 | r22        | WycombeWycombe | 2 - 2 | AFC WimbledonAFC Wimbledon |
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| 29 Dec 21 | r25        | Oxford UtdOxford Utd | 3 - 0 | AFC WimbledonAFC Wimbledon |
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| 11 Jan 22 | r12        | Milton Keynes DonsMilton Keynes | 1 - 0 | AFC WimbledonAFC Wimbledon |
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| 15 Jan 22 | r28        | AFC WimbledonAFC Wimbledon | 0 - 0 | MorecambeMorecambe |
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| 18 Jan 22 | r23        | AFC WimbledonAFC Wimbledon | 0 - 0 | PortsmouthPortsmouth |
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| 22 Jan 22 | r29        | BurtonBurton | 1 - 1 | AFC WimbledonAFC Wimbledon |
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| 25 Jan 22 | r27        | AFC WimbledonAFC Wimbledon | 0 - 2 | IpswichIpswich |
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| 29 Jan 22 | r30        | AFC WimbledonAFC Wimbledon | 1 - 1 | ShrewsburyShrewsbury |
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| 01 Feb 22 | r17        | AFC WimbledonAFC Wimbledon | 2 - 2 | CheltenhamCheltenham |
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| 05 Feb 22 | r31        | CharltonCharlton | 3 - 2 | AFC WimbledonAFC Wimbledon |
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| 08 Feb 22 | r32        | AFC WimbledonAFC Wimbledon | 0 - 1 | RotherhamRotherham |
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| 12 Feb 22 | r33        | AFC WimbledonAFC Wimbledon | 1 - 1 | SunderlandSunderland |
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| 19 Feb 22 | r34        | BoltonBolton | 4 - 0 | AFC WimbledonAFC Wimbledon |
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| 22 Feb 22 | r35        | GillinghamGillingham | 0 - 0 | AFC WimbledonAFC Wimbledon |
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| 26 Feb 22 | r36        | AFC WimbledonAFC Wimbledon | 2 - 2 | DoncasterDoncaster |
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| 05 Mar 22 | r37        | WiganWigan | 1 - 0 | AFC WimbledonAFC Wimbledon |
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| 08 Mar 22 | r26        | PlymouthPlymouth | 2 - 0 | AFC WimbledonAFC Wimbledon |
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| 12 Mar 22 | r38        | AFC WimbledonAFC Wimbledon | 0 - 2 | LincolnLincoln |
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| 19 Mar 22 | r39        | CheltenhamCheltenham | 3 - 1 | AFC WimbledonAFC Wimbledon |
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| 26 Mar 22 | r40        | AFC WimbledonAFC Wimbledon | 0 - 1 | Cambridge UnitedCambridge Uni |
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| 02 Apr 22 | r41        | Sheffield WedsSheffield Wed | 2 - 1 | AFC WimbledonAFC Wimbledon |
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| 05 Apr 22 | r24        | AFC WimbledonAFC Wimbledon | 1 - 1 | CharltonCharlton |
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| 09 Apr 22 | r42        | AFC WimbledonAFC Wimbledon | 1 - 1 | Milton Keynes DonsMilton Keynes |
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| 15 Apr 22 | r43        | CreweCrewe | 3 - 1 | AFC WimbledonAFC Wimbledon |
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| 18 Apr 22 | r44        | AFC WimbledonAFC Wimbledon | 1 - 1 | WycombeWycombe |
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| 23 Apr 22 | r45        | Fleetwood TownFleetwood Tow | 1 - 1 | AFC WimbledonAFC Wimbledon |
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| 30 Apr 22 | r46        | AFC WimbledonAFC Wimbledon | 3 - 4 | AccringtonAccrington |