| 12 Sep 21 | r01        | WashingtonWashington | 16 - 20 | Los Angeles ChargersLos Angeles C |
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| 19 Sep 21 | r02        | Los Angeles ChargersLos Angeles C | 17 - 20 | Dallas CowboysDallas Cowboy |
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| 26 Sep 21 | r03        | Kansas City ChiefsKansas City C | 24 - 30 | Los Angeles ChargersLos Angeles C |
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| 05 Oct 21 | r04        | Los Angeles ChargersLos Angeles C | 28 - 14 | Las Vegas RaidersLas Vegas Rai |
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| 10 Oct 21 | r05        | Los Angeles ChargersLos Angeles C | 47 - 42 | Cleveland BrownsCleveland Bro |
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| 17 Oct 21 | r06        | Baltimore RavensBaltimore Rav | 34 - 6 | Los Angeles ChargersLos Angeles C |
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| 31 Oct 21 | r08        | Los Angeles ChargersLos Angeles C | 24 - 27 | New England PatriotsNew England P |
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| 07 Nov 21 | r09        | Philadelphia EaglesPhiladelphia | 24 - 27 | Los Angeles ChargersLos Angeles C |
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| 14 Nov 21 | r10        | Los Angeles ChargersLos Angeles C | 20 - 27 | Minnesota VikingsMinnesota Vik |
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| 22 Nov 21 | r11        | Los Angeles ChargersLos Angeles C | 41 - 37 | Pittsburgh SteelersPittsburgh St |
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| 28 Nov 21 | r12        | Denver BroncosDenver Bronco | 28 - 13 | Los Angeles ChargersLos Angeles C |
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| 05 Dec 21 | r13        | Cincinnati BengalsCincinnati Be | 22 - 41 | Los Angeles ChargersLos Angeles C |
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| 12 Dec 21 | r14        | Los Angeles ChargersLos Angeles C | 37 - 21 | New York GiantsNew York Gian |
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| 17 Dec 21 | r15        | Los Angeles ChargersLos Angeles C | 28 - 34 | Kansas City ChiefsKansas City C |
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| 26 Dec 21 | r16        | Houston TexansHouston Texan | 41 - 29 | Los Angeles ChargersLos Angeles C |
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| 02 Jan 22 | r17        | Los Angeles ChargersLos Angeles C | 34 - 13 | Denver BroncosDenver Bronco |
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| 10 Jan 22 | r18        | Las Vegas RaidersLas Vegas Rai | 35 - 32 | Los Angeles ChargersLos Angeles C |