| 12 Sep 21 | r01        | New York GiantsNew York Gian | 13 - 27 | Denver BroncosDenver Bronco |
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| 19 Sep 21 | r02        | Jacksonville JaguarsJacksonville | 13 - 23 | Denver BroncosDenver Bronco |
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| 26 Sep 21 | r03        | Denver BroncosDenver Bronco | 26 - 0 | New York JetsNew York Jets |
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| 03 Oct 21 | r04        | Denver BroncosDenver Bronco | 7 - 23 | Baltimore RavensBaltimore Rav |
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| 10 Oct 21 | r05        | Pittsburgh SteelersPittsburgh St | 27 - 19 | Denver BroncosDenver Bronco |
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| 17 Oct 21 | r06        | Denver BroncosDenver Bronco | 24 - 34 | Las Vegas RaidersLas Vegas Rai |
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| 22 Oct 21 | r07        | Cleveland BrownsCleveland Bro | 17 - 14 | Denver BroncosDenver Bronco |
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| 31 Oct 21 | r08        | Denver BroncosDenver Bronco | 17 - 10 | WashingtonWashington |
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| 07 Nov 21 | r09        | Dallas CowboysDallas Cowboy | 16 - 30 | Denver BroncosDenver Bronco |
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| 14 Nov 21 | r10        | Denver BroncosDenver Bronco | 13 - 30 | Philadelphia EaglesPhiladelphia |
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| 28 Nov 21 | r12        | Denver BroncosDenver Bronco | 28 - 13 | Los Angeles ChargersLos Angeles C |
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| 06 Dec 21 | r13        | Kansas City ChiefsKansas City C | 22 - 9 | Denver BroncosDenver Bronco |
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| 12 Dec 21 | r14        | Denver BroncosDenver Bronco | 38 - 10 | Detroit LionsDetroit Lions |
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| 19 Dec 21 | r15        | Denver BroncosDenver Bronco | 10 - 15 | Cincinnati BengalsCincinnati Be |
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| 26 Dec 21 | r16        | Las Vegas RaidersLas Vegas Rai | 17 - 13 | Denver BroncosDenver Bronco |
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| 02 Jan 22 | r17        | Los Angeles ChargersLos Angeles C | 34 - 13 | Denver BroncosDenver Bronco |
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| 08 Jan 22 | r18        | Denver BroncosDenver Bronco | 24 - 28 | Kansas City ChiefsKansas City C |