| 10 Sep 06 | r01        | Cleveland BrownsCleveland Bro | 14 - 19 | New Orleans SaintsNew Orleans S |
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| 17 Sep 06 | r02        | Cincinnati BengalsCincinnati Be | 34 - 17 | Cleveland BrownsCleveland Bro |
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| 24 Sep 06 | r03        | Cleveland BrownsCleveland Bro | 14 - 15 | Baltimore RavensBaltimore Rav |
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| 01 Oct 06 | r04        | Oakland RaidersOakland Raide | 21 - 24 | Cleveland BrownsCleveland Bro |
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| 08 Oct 06 | r05        | Carolina PanthersCarolina Pant | 20 - 12 | Cleveland BrownsCleveland Bro |
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| 22 Oct 06 | r07        | Cleveland BrownsCleveland Bro | 7 - 17 | Denver BroncosDenver Bronco |
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| 29 Oct 06 | r08        | Cleveland BrownsCleveland Bro | 20 - 13 | New York JetsNew York Jets |
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| 05 Nov 06 | r09        | San Diego ChargersSan Diego Cha | 32 - 25 | Cleveland BrownsCleveland Bro |
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| 12 Nov 06 | r10        | Atlanta FalconsAtlanta Falco | 13 - 17 | Cleveland BrownsCleveland Bro |
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| 19 Nov 06 | r11        | Cleveland BrownsCleveland Bro | 20 - 24 | Pittsburgh SteelersPittsburgh St |
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| 26 Nov 06 | r12        | Cleveland BrownsCleveland Bro | 0 - 30 | Cincinnati BengalsCincinnati Be |
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| 03 Dec 06 | r13        | Cleveland BrownsCleveland Bro | 31 - 28 | Kansas City ChiefsKansas City C |
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| 07 Dec 06 | r14        | Pittsburgh SteelersPittsburgh St | 27 - 7 | Cleveland BrownsCleveland Bro |
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| 17 Dec 06 | r15        | Baltimore RavensBaltimore Rav | 27 - 17 | Cleveland BrownsCleveland Bro |
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| 24 Dec 06 | r16        | Cleveland BrownsCleveland Bro | 7 - 22 | Tampa Bay BuccaneersTampa Bay Buc |
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| 31 Dec 06 | r17        | Houston TexansHouston Texan | 14 - 6 | Cleveland BrownsCleveland Bro |