| 03 Sep 00 | r01        | Cleveland BrownsCleveland Bro | 7 - 27 | Jacksonville JaguarsJacksonville |
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| 10 Sep 00 | r02        | Cincinnati BengalsCincinnati Be | 7 - 24 | Cleveland BrownsCleveland Bro |
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| 17 Sep 00 | r03        | Cleveland BrownsCleveland Bro | 23 - 20 | Pittsburgh SteelersPittsburgh St |
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| 24 Sep 00 | r04        | Oakland RaidersOakland Raide | 36 - 10 | Cleveland BrownsCleveland Bro |
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| 01 Oct 00 | r05        | Cleveland BrownsCleveland Bro | 0 - 12 | Baltimore RavensBaltimore Rav |
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| 08 Oct 00 | r06        | Arizona CardinalsArizona Cardi | 29 - 21 | Cleveland BrownsCleveland Bro |
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| 15 Oct 00 | r07        | Denver BroncosDenver Bronco | 44 - 10 | Cleveland BrownsCleveland Bro |
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| 22 Oct 00 | r08        | Pittsburgh SteelersPittsburgh St | 22 - 0 | Cleveland BrownsCleveland Bro |
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| 29 Oct 00 | r09        | Cleveland BrownsCleveland Bro | 3 - 12 | Cincinnati BengalsCincinnati Be |
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| 05 Nov 00 | r10        | Cleveland BrownsCleveland Bro | 3 - 24 | New York GiantsNew York Gian |
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| 12 Nov 00 | r11        | Cleveland BrownsCleveland Bro | 19 - 11 | New England PatriotsNew England P |
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| 19 Nov 00 | r12        | Tennessee TitansTennessee Tit | 24 - 10 | Cleveland BrownsCleveland Bro |
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| 26 Nov 00 | r13        | Baltimore RavensBaltimore Rav | 44 - 7 | Cleveland BrownsCleveland Bro |
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| 03 Dec 00 | r14        | Jacksonville JaguarsJacksonville | 48 - 0 | Cleveland BrownsCleveland Bro |
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| 10 Dec 00 | r15        | Cleveland BrownsCleveland Bro | 24 - 35 | Philadelphia EaglesPhiladelphia |
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| 17 Dec 00 | r16        | Cleveland BrownsCleveland Bro | 0 - 24 | Tennessee TitansTennessee Tit |