| 12 Sep 99 | r01        | Tampa Bay BuccaneersTampa Bay Buc | 17 - 13 | New York GiantsNew York Gian |
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| 19 Sep 99 | r02        | New York GiantsNew York Gian | 50 - 21 | Washington CommandersWashington Co |
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| 27 Sep 99 | r03        | New England PatriotsNew England P | 16 - 14 | New York GiantsNew York Gian |
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| 03 Oct 99 | r04        | New York GiantsNew York Gian | 16 - 15 | Philadelphia EaglesPhiladelphia |
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| 10 Oct 99 | r05        | Arizona CardinalsArizona Cardi | 14 - 3 | New York GiantsNew York Gian |
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| 19 Oct 99 | r06        | New York GiantsNew York Gian | 13 - 10 | Dallas CowboysDallas Cowboy |
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| 24 Oct 99 | r07        | New York GiantsNew York Gian | 31 - 3 | New Orleans SaintsNew Orleans S |
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| 31 Oct 99 | r08        | Philadelphia EaglesPhiladelphia | 23 - 17 | New York GiantsNew York Gian |
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| 14 Nov 99 | r10        | New York GiantsNew York Gian | 27 - 19 | Indianapolis ColtsIndianapolis |
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| 21 Nov 99 | r11        | Washington CommandersWashington Co | 23 - 13 | New York GiantsNew York Gian |
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| 28 Nov 99 | r12        | New York GiantsNew York Gian | 34 - 24 | Arizona CardinalsArizona Cardi |
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| 05 Dec 99 | r13        | New York GiantsNew York Gian | 41 - 28 | New York JetsNew York Jets |
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| 12 Dec 99 | r14        | Buffalo BillsBuffalo Bills | 19 - 17 | New York GiantsNew York Gian |
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| 19 Dec 99 | r15        | Los Angeles RamsLos Angeles R | 31 - 10 | New York GiantsNew York Gian |
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| 26 Dec 99 | r16        | New York GiantsNew York Gian | 34 - 17 | Minnesota VikingsMinnesota Vik |
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| 02 Jan 00 | r17        | Dallas CowboysDallas Cowboy | 26 - 18 | New York GiantsNew York Gian |