| 01 Sep 91 | r01        | Cleveland BrownsCleveland Bro | 14 - 26 | Dallas CowboysDallas Cowboy |
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| 08 Sep 91 | r02        | New England PatriotsNew England P | 0 - 20 | Cleveland BrownsCleveland Bro |
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| 15 Sep 91 | r03        | Cleveland BrownsCleveland Bro | 14 - 13 | Cincinnati BengalsCincinnati Be |
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| 22 Sep 91 | r04        | New York GiantsNew York Gian | 13 - 10 | Cleveland BrownsCleveland Bro |
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| 06 Oct 91 | r06        | Cleveland BrownsCleveland Bro | 14 - 17 | New York JetsNew York Jets |
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| 13 Oct 91 | r07        | Washington CommandersWashington Co | 42 - 17 | Cleveland BrownsCleveland Bro |
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| 20 Oct 91 | r08        | Los Angeles ChargersLos Angeles C | 24 - 30 | Cleveland BrownsCleveland Bro |
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| 27 Oct 91 | r09        | Cleveland BrownsCleveland Bro | 17 - 14 | Pittsburgh SteelersPittsburgh St |
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| 03 Nov 91 | r10        | Cincinnati BengalsCincinnati Be | 23 - 21 | Cleveland BrownsCleveland Bro |
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| 10 Nov 91 | r11        | Cleveland BrownsCleveland Bro | 30 - 32 | Philadelphia EaglesPhiladelphia |
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| 18 Nov 91 | r12        | Tennessee TitansTennessee Tit | 28 - 24 | Cleveland BrownsCleveland Bro |
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| 24 Nov 91 | r13        | Cleveland BrownsCleveland Bro | 20 - 15 | Kansas City ChiefsKansas City C |
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| 01 Dec 91 | r14        | Indianapolis ColtsIndianapolis | 0 - 31 | Cleveland BrownsCleveland Bro |
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| 08 Dec 91 | r15        | Cleveland BrownsCleveland Bro | 7 - 17 | Denver BroncosDenver Bronco |
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| 15 Dec 91 | r16        | Cleveland BrownsCleveland Bro | 14 - 17 | Tennessee TitansTennessee Tit |
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| 22 Dec 91 | r17        | Pittsburgh SteelersPittsburgh St | 17 - 10 | Cleveland BrownsCleveland Bro |