| 04 Sep 88 | r01        | New Orleans SaintsNew Orleans S | 33 - 34 | San Francisco 49ersSan Francisco |
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| 11 Sep 88 | r02        | New York GiantsNew York Gian | 17 - 20 | San Francisco 49ersSan Francisco |
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| 18 Sep 88 | r03        | San Francisco 49ersSan Francisco | 17 - 34 | Atlanta FalconsAtlanta Falco |
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| 25 Sep 88 | r04        | Seattle SeahawksSeattle Seaha | 7 - 38 | San Francisco 49ersSan Francisco |
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| 02 Oct 88 | r05        | San Francisco 49ersSan Francisco | 20 - 13 | Detroit LionsDetroit Lions |
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| 09 Oct 88 | r06        | San Francisco 49ersSan Francisco | 13 - 16 | Denver BroncosDenver Bronco |
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| 16 Oct 88 | r07        | Los Angeles RamsLos Angeles R | 21 - 24 | San Francisco 49ersSan Francisco |
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| 25 Oct 88 | r08        | Chicago BearsChicago Bears | 10 - 9 | San Francisco 49ersSan Francisco |
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| 30 Oct 88 | r09        | San Francisco 49ersSan Francisco | 24 - 21 | Minnesota VikingsMinnesota Vik |
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| 06 Nov 88 | r10        | Arizona CardinalsArizona Cardi | 24 - 23 | San Francisco 49ersSan Francisco |
| 13 Nov 88 | r10        | San Francisco 49ersSan Francisco | 3 - 9 | Las Vegas RaidersLas Vegas Rai |
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| 22 Nov 88 | r12        | San Francisco 49ersSan Francisco | 37 - 21 | Washington CommandersWashington Co |
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| 27 Nov 88 | r13        | Los Angeles ChargersLos Angeles C | 10 - 48 | San Francisco 49ersSan Francisco |
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| 04 Dec 88 | r14        | Atlanta FalconsAtlanta Falco | 3 - 13 | San Francisco 49ersSan Francisco |
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| 12 Dec 88 | r15        | San Francisco 49ersSan Francisco | 30 - 17 | New Orleans SaintsNew Orleans S |
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| 19 Dec 88 | r16        | San Francisco 49ersSan Francisco | 16 - 38 | Los Angeles RamsLos Angeles R |
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| 01 Jan 89 | QF        | San Francisco 49ersSan Francisco | 34 - 9 | Minnesota VikingsMinnesota Vik |
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| 08 Jan 89 | SF        | Chicago BearsChicago Bears | 3 - 28 | San Francisco 49ersSan Francisco |
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| 22 Jan 89 | Final        | San Francisco 49ersSan Francisco | 20 - 16 | Cincinnati BengalsCincinnati Be |