| 04 Sep 88 | r01        | Cincinnati BengalsCincinnati Be | 21 - 14 | Arizona CardinalsArizona Cardi |
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| 13 Sep 88 | r02        | Arizona CardinalsArizona Cardi | 14 - 17 | Dallas CowboysDallas Cowboy |
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| 18 Sep 88 | r03        | Tampa Bay BuccaneersTampa Bay Buc | 24 - 30 | Arizona CardinalsArizona Cardi |
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| 25 Sep 88 | r04        | Arizona CardinalsArizona Cardi | 30 - 21 | Washington CommandersWashington Co |
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| 02 Oct 88 | r05        | Los Angeles RamsLos Angeles R | 27 - 41 | Arizona CardinalsArizona Cardi |
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| 09 Oct 88 | r06        | Arizona CardinalsArizona Cardi | 31 - 14 | Pittsburgh SteelersPittsburgh St |
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| 16 Oct 88 | r07        | Washington CommandersWashington Co | 33 - 17 | Arizona CardinalsArizona Cardi |
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| 23 Oct 88 | r08        | Arizona CardinalsArizona Cardi | 21 - 29 | Cleveland BrownsCleveland Bro |
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| 30 Oct 88 | r09        | Dallas CowboysDallas Cowboy | 10 - 16 | Arizona CardinalsArizona Cardi |
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| 06 Nov 88 | r10        | Arizona CardinalsArizona Cardi | 24 - 23 | San Francisco 49ersSan Francisco |
| 13 Nov 88 | r10        | Arizona CardinalsArizona Cardi | 24 - 17 | New York GiantsNew York Gian |
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| 20 Nov 88 | r12        | Tennessee TitansTennessee Tit | 38 - 20 | Arizona CardinalsArizona Cardi |
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| 27 Nov 88 | r13        | Philadelphia EaglesPhiladelphia | 31 - 21 | Arizona CardinalsArizona Cardi |
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| 04 Dec 88 | r14        | New York GiantsNew York Gian | 44 - 7 | Arizona CardinalsArizona Cardi |
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| 10 Dec 88 | r15        | Arizona CardinalsArizona Cardi | 17 - 23 | Philadelphia EaglesPhiladelphia |
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| 18 Dec 88 | r16        | Arizona CardinalsArizona Cardi | 17 - 26 | Green Bay PackersGreen Bay Pac |