| 04 Sep 88 | r01        | Tampa Bay BuccaneersTampa Bay Buc | 14 - 41 | Philadelphia EaglesPhiladelphia |
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| 11 Sep 88 | r02        | Green Bay PackersGreen Bay Pac | 10 - 13 | Tampa Bay BuccaneersTampa Bay Buc |
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| 18 Sep 88 | r03        | Tampa Bay BuccaneersTampa Bay Buc | 24 - 30 | Arizona CardinalsArizona Cardi |
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| 25 Sep 88 | r04        | New Orleans SaintsNew Orleans S | 13 - 9 | Tampa Bay BuccaneersTampa Bay Buc |
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| 02 Oct 88 | r05        | Tampa Bay BuccaneersTampa Bay Buc | 27 - 24 | Green Bay PackersGreen Bay Pac |
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| 09 Oct 88 | r06        | Minnesota VikingsMinnesota Vik | 14 - 13 | Tampa Bay BuccaneersTampa Bay Buc |
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| 16 Oct 88 | r07        | Indianapolis ColtsIndianapolis | 35 - 31 | Tampa Bay BuccaneersTampa Bay Buc |
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| 23 Oct 88 | r08        | Tampa Bay BuccaneersTampa Bay Buc | 20 - 49 | Minnesota VikingsMinnesota Vik |
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| 30 Oct 88 | r09        | Tampa Bay BuccaneersTampa Bay Buc | 14 - 17 | Miami DolphinsMiami Dolphin |
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| 06 Nov 88 | r10        | Chicago BearsChicago Bears | 28 - 10 | Tampa Bay BuccaneersTampa Bay Buc |
| 13 Nov 88 | r10        | Detroit LionsDetroit Lions | 20 - 23 | Tampa Bay BuccaneersTampa Bay Buc |
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| 20 Nov 88 | r12        | Tampa Bay BuccaneersTampa Bay Buc | 15 - 27 | Chicago BearsChicago Bears |
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| 27 Nov 88 | r13        | Atlanta FalconsAtlanta Falco | 17 - 10 | Tampa Bay BuccaneersTampa Bay Buc |
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| 04 Dec 88 | r14        | Tampa Bay BuccaneersTampa Bay Buc | 10 - 5 | Buffalo BillsBuffalo Bills |
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| 11 Dec 88 | r15        | New England PatriotsNew England P | 10 - 7 | Tampa Bay BuccaneersTampa Bay Buc |
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| 18 Dec 88 | r16        | Tampa Bay BuccaneersTampa Bay Buc | 21 - 10 | Detroit LionsDetroit Lions |