| 04 Sep 88 | r01        | New Orleans SaintsNew Orleans S | 33 - 34 | San Francisco 49ersSan Francisco |
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| 11 Sep 88 | r02        | Atlanta FalconsAtlanta Falco | 21 - 29 | New Orleans SaintsNew Orleans S |
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| 18 Sep 88 | r03        | Detroit LionsDetroit Lions | 14 - 22 | New Orleans SaintsNew Orleans S |
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| 25 Sep 88 | r04        | New Orleans SaintsNew Orleans S | 13 - 9 | Tampa Bay BuccaneersTampa Bay Buc |
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| 04 Oct 88 | r05        | New Orleans SaintsNew Orleans S | 20 - 17 | Dallas CowboysDallas Cowboy |
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| 09 Oct 88 | r06        | Los Angeles ChargersLos Angeles C | 17 - 23 | New Orleans SaintsNew Orleans S |
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| 16 Oct 88 | r07        | Seattle SeahawksSeattle Seaha | 19 - 20 | New Orleans SaintsNew Orleans S |
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| 23 Oct 88 | r08        | New Orleans SaintsNew Orleans S | 20 - 6 | Las Vegas RaidersLas Vegas Rai |
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| 30 Oct 88 | r09        | New Orleans SaintsNew Orleans S | 10 - 12 | Los Angeles RamsLos Angeles R |
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| 06 Nov 88 | r10        | Washington CommandersWashington Co | 27 - 24 | New Orleans SaintsNew Orleans S |
| 13 Nov 88 | r10        | Los Angeles RamsLos Angeles R | 10 - 14 | New Orleans SaintsNew Orleans S |
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| 20 Nov 88 | r12        | New Orleans SaintsNew Orleans S | 42 - 0 | Denver BroncosDenver Bronco |
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| 28 Nov 88 | r13        | New Orleans SaintsNew Orleans S | 12 - 13 | New York GiantsNew York Gian |
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| 04 Dec 88 | r14        | Minnesota VikingsMinnesota Vik | 45 - 3 | New Orleans SaintsNew Orleans S |
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| 12 Dec 88 | r15        | San Francisco 49ersSan Francisco | 30 - 17 | New Orleans SaintsNew Orleans S |
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| 18 Dec 88 | r16        | New Orleans SaintsNew Orleans S | 10 - 9 | Atlanta FalconsAtlanta Falco |