| 04 Sep 88 | r01        | Detroit LionsDetroit Lions | 31 - 17 | Atlanta FalconsAtlanta Falco |
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| 11 Sep 88 | r02        | Los Angeles RamsLos Angeles R | 17 - 10 | Detroit LionsDetroit Lions |
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| 18 Sep 88 | r03        | Detroit LionsDetroit Lions | 14 - 22 | New Orleans SaintsNew Orleans S |
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| 25 Sep 88 | r04        | Detroit LionsDetroit Lions | 10 - 17 | New York JetsNew York Jets |
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| 02 Oct 88 | r05        | San Francisco 49ersSan Francisco | 20 - 13 | Detroit LionsDetroit Lions |
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| 09 Oct 88 | r06        | Detroit LionsDetroit Lions | 7 - 24 | Chicago BearsChicago Bears |
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| 16 Oct 88 | r07        | New York GiantsNew York Gian | 30 - 10 | Detroit LionsDetroit Lions |
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| 23 Oct 88 | r08        | Kansas City ChiefsKansas City C | 6 - 7 | Detroit LionsDetroit Lions |
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| 30 Oct 88 | r09        | Detroit LionsDetroit Lions | 10 - 13 | New York GiantsNew York Gian |
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| 06 Nov 88 | r10        | Minnesota VikingsMinnesota Vik | 44 - 17 | Detroit LionsDetroit Lions |
| 13 Nov 88 | r10        | Detroit LionsDetroit Lions | 20 - 23 | Tampa Bay BuccaneersTampa Bay Buc |
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| 20 Nov 88 | r12        | Green Bay PackersGreen Bay Pac | 9 - 19 | Detroit LionsDetroit Lions |
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| 24 Nov 88 | r13        | Detroit LionsDetroit Lions | 0 - 23 | Minnesota VikingsMinnesota Vik |
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| 04 Dec 88 | r14        | Detroit LionsDetroit Lions | 30 - 14 | Green Bay PackersGreen Bay Pac |
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| 11 Dec 88 | r15        | Chicago BearsChicago Bears | 13 - 12 | Detroit LionsDetroit Lions |
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| 18 Dec 88 | r16        | Tampa Bay BuccaneersTampa Bay Buc | 21 - 10 | Detroit LionsDetroit Lions |