| 04 Sep 88 | r01        | Tampa Bay BuccaneersTampa Bay Buc | 14 - 41 | Philadelphia EaglesPhiladelphia |
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| 11 Sep 88 | r02        | Philadelphia EaglesPhiladelphia | 24 - 28 | Cincinnati BengalsCincinnati Be |
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| 18 Sep 88 | r03        | Washington CommandersWashington Co | 17 - 10 | Philadelphia EaglesPhiladelphia |
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| 25 Sep 88 | r04        | Minnesota VikingsMinnesota Vik | 23 - 21 | Philadelphia EaglesPhiladelphia |
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| 02 Oct 88 | r05        | Philadelphia EaglesPhiladelphia | 32 - 23 | Tennessee TitansTennessee Tit |
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| 11 Oct 88 | r06        | Philadelphia EaglesPhiladelphia | 24 - 13 | New York GiantsNew York Gian |
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| 16 Oct 88 | r07        | Cleveland BrownsCleveland Bro | 19 - 3 | Philadelphia EaglesPhiladelphia |
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| 23 Oct 88 | r08        | Philadelphia EaglesPhiladelphia | 24 - 23 | Dallas CowboysDallas Cowboy |
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| 30 Oct 88 | r09        | Philadelphia EaglesPhiladelphia | 24 - 27 | Atlanta FalconsAtlanta Falco |
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| 06 Nov 88 | r10        | Philadelphia EaglesPhiladelphia | 30 - 24 | Los Angeles RamsLos Angeles R |
| 13 Nov 88 | r10        | Pittsburgh SteelersPittsburgh St | 26 - 27 | Philadelphia EaglesPhiladelphia |
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| 20 Nov 88 | r12        | New York GiantsNew York Gian | 17 - 23 | Philadelphia EaglesPhiladelphia |
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| 27 Nov 88 | r13        | Philadelphia EaglesPhiladelphia | 31 - 21 | Arizona CardinalsArizona Cardi |
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| 04 Dec 88 | r14        | Philadelphia EaglesPhiladelphia | 19 - 20 | Washington CommandersWashington Co |
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| 10 Dec 88 | r15        | Arizona CardinalsArizona Cardi | 17 - 23 | Philadelphia EaglesPhiladelphia |
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| 18 Dec 88 | r16        | Dallas CowboysDallas Cowboy | 7 - 23 | Philadelphia EaglesPhiladelphia |
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| 31 Dec 88 | QF        | Chicago BearsChicago Bears | 20 - 12 | Philadelphia EaglesPhiladelphia |