| 04 Sep 88 | r01        | Kansas City ChiefsKansas City C | 3 - 6 | Cleveland BrownsCleveland Bro |
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| 11 Sep 88 | r02        | Seattle SeahawksSeattle Seaha | 31 - 10 | Kansas City ChiefsKansas City C |
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| 18 Sep 88 | r03        | Kansas City ChiefsKansas City C | 20 - 13 | Denver BroncosDenver Bronco |
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| 25 Sep 88 | r04        | Kansas City ChiefsKansas City C | 23 - 24 | Los Angeles ChargersLos Angeles C |
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| 02 Oct 88 | r05        | New York JetsNew York Jets | 17 - 17 | Kansas City ChiefsKansas City C |
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| 09 Oct 88 | r06        | Tennessee TitansTennessee Tit | 7 - 6 | Kansas City ChiefsKansas City C |
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| 16 Oct 88 | r07        | Kansas City ChiefsKansas City C | 17 - 27 | Las Vegas RaidersLas Vegas Rai |
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| 23 Oct 88 | r08        | Kansas City ChiefsKansas City C | 6 - 7 | Detroit LionsDetroit Lions |
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| 30 Oct 88 | r09        | Las Vegas RaidersLas Vegas Rai | 17 - 10 | Kansas City ChiefsKansas City C |
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| 06 Nov 88 | r10        | Denver BroncosDenver Bronco | 17 - 11 | Kansas City ChiefsKansas City C |
| 13 Nov 88 | r10        | Kansas City ChiefsKansas City C | 31 - 28 | Cincinnati BengalsCincinnati Be |
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| 20 Nov 88 | r12        | Kansas City ChiefsKansas City C | 27 - 24 | Seattle SeahawksSeattle Seaha |
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| 27 Nov 88 | r13        | Pittsburgh SteelersPittsburgh St | 16 - 10 | Kansas City ChiefsKansas City C |
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| 04 Dec 88 | r14        | Kansas City ChiefsKansas City C | 38 - 34 | New York JetsNew York Jets |
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| 11 Dec 88 | r15        | New York GiantsNew York Gian | 28 - 12 | Kansas City ChiefsKansas City C |
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| 18 Dec 88 | r16        | Los Angeles ChargersLos Angeles C | 24 - 13 | Kansas City ChiefsKansas City C |