| 04 Sep 88 | r01        | Indianapolis ColtsIndianapolis | 14 - 17 | Tennessee TitansTennessee Tit |
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| 11 Sep 88 | r02        | Indianapolis ColtsIndianapolis | 13 - 17 | Chicago BearsChicago Bears |
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| 20 Sep 88 | r03        | Cleveland BrownsCleveland Bro | 23 - 17 | Indianapolis ColtsIndianapolis |
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| 25 Sep 88 | r04        | Indianapolis ColtsIndianapolis | 15 - 13 | Miami DolphinsMiami Dolphin |
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| 02 Oct 88 | r05        | New England PatriotsNew England P | 21 - 17 | Indianapolis ColtsIndianapolis |
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| 09 Oct 88 | r06        | Buffalo BillsBuffalo Bills | 34 - 23 | Indianapolis ColtsIndianapolis |
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| 16 Oct 88 | r07        | Indianapolis ColtsIndianapolis | 35 - 31 | Tampa Bay BuccaneersTampa Bay Buc |
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| 23 Oct 88 | r08        | Los Angeles ChargersLos Angeles C | 0 - 16 | Indianapolis ColtsIndianapolis |
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| 01 Nov 88 | r09        | Indianapolis ColtsIndianapolis | 55 - 23 | Denver BroncosDenver Bronco |
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| 06 Nov 88 | r10        | Indianapolis ColtsIndianapolis | 38 - 14 | New York JetsNew York Jets |
| 13 Nov 88 | r10        | Green Bay PackersGreen Bay Pac | 13 - 20 | Indianapolis ColtsIndianapolis |
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| 20 Nov 88 | r12        | Minnesota VikingsMinnesota Vik | 12 - 3 | Indianapolis ColtsIndianapolis |
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| 27 Nov 88 | r13        | Indianapolis ColtsIndianapolis | 24 - 21 | New England PatriotsNew England P |
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| 04 Dec 88 | r14        | Miami DolphinsMiami Dolphin | 28 - 31 | Indianapolis ColtsIndianapolis |
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| 10 Dec 88 | r15        | New York JetsNew York Jets | 34 - 16 | Indianapolis ColtsIndianapolis |
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| 18 Dec 88 | r16        | Indianapolis ColtsIndianapolis | 17 - 14 | Buffalo BillsBuffalo Bills |