| 04 Sep 88 | r01        | Pittsburgh SteelersPittsburgh St | 24 - 21 | Dallas CowboysDallas Cowboy |
| |
| 11 Sep 88 | r02        | Washington CommandersWashington Co | 30 - 29 | Pittsburgh SteelersPittsburgh St |
| |
| 18 Sep 88 | r03        | Pittsburgh SteelersPittsburgh St | 12 - 17 | Cincinnati BengalsCincinnati Be |
| |
| 25 Sep 88 | r04        | Buffalo BillsBuffalo Bills | 36 - 28 | Pittsburgh SteelersPittsburgh St |
| |
| 02 Oct 88 | r05        | Pittsburgh SteelersPittsburgh St | 9 - 23 | Cleveland BrownsCleveland Bro |
| |
| 09 Oct 88 | r06        | Arizona CardinalsArizona Cardi | 31 - 14 | Pittsburgh SteelersPittsburgh St |
| |
| 16 Oct 88 | r07        | Pittsburgh SteelersPittsburgh St | 14 - 34 | Tennessee TitansTennessee Tit |
| |
| 23 Oct 88 | r08        | Pittsburgh SteelersPittsburgh St | 39 - 21 | Denver BroncosDenver Bronco |
| |
| 30 Oct 88 | r09        | New York JetsNew York Jets | 24 - 20 | Pittsburgh SteelersPittsburgh St |
| |
| 06 Nov 88 | r10        | Cincinnati BengalsCincinnati Be | 42 - 7 | Pittsburgh SteelersPittsburgh St |
| 13 Nov 88 | r10        | Pittsburgh SteelersPittsburgh St | 26 - 27 | Philadelphia EaglesPhiladelphia |
| |
| 20 Nov 88 | r12        | Cleveland BrownsCleveland Bro | 27 - 7 | Pittsburgh SteelersPittsburgh St |
| |
| 27 Nov 88 | r13        | Pittsburgh SteelersPittsburgh St | 16 - 10 | Kansas City ChiefsKansas City C |
| |
| 05 Dec 88 | r14        | Tennessee TitansTennessee Tit | 34 - 37 | Pittsburgh SteelersPittsburgh St |
| |
| 11 Dec 88 | r15        | Los Angeles ChargersLos Angeles C | 20 - 14 | Pittsburgh SteelersPittsburgh St |
| |
| 18 Dec 88 | r16        | Pittsburgh SteelersPittsburgh St | 40 - 24 | Miami DolphinsMiami Dolphin |