| 04 Sep 88 | r01        | New England PatriotsNew England P | 28 - 3 | New York JetsNew York Jets |
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| 11 Sep 88 | r02        | Minnesota VikingsMinnesota Vik | 36 - 6 | New England PatriotsNew England P |
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| 18 Sep 88 | r03        | New England PatriotsNew England P | 14 - 16 | Buffalo BillsBuffalo Bills |
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| 25 Sep 88 | r04        | Tennessee TitansTennessee Tit | 31 - 6 | New England PatriotsNew England P |
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| 02 Oct 88 | r05        | New England PatriotsNew England P | 21 - 17 | Indianapolis ColtsIndianapolis |
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| 09 Oct 88 | r06        | Green Bay PackersGreen Bay Pac | 45 - 3 | New England PatriotsNew England P |
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| 16 Oct 88 | r07        | New England PatriotsNew England P | 27 - 21 | Cincinnati BengalsCincinnati Be |
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| 23 Oct 88 | r08        | Buffalo BillsBuffalo Bills | 23 - 20 | New England PatriotsNew England P |
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| 30 Oct 88 | r09        | New England PatriotsNew England P | 30 - 7 | Chicago BearsChicago Bears |
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| 06 Nov 88 | r10        | New England PatriotsNew England P | 21 - 10 | Miami DolphinsMiami Dolphin |
| 13 Nov 88 | r10        | New York JetsNew York Jets | 13 - 14 | New England PatriotsNew England P |
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| 21 Nov 88 | r12        | Miami DolphinsMiami Dolphin | 3 - 6 | New England PatriotsNew England P |
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| 27 Nov 88 | r13        | Indianapolis ColtsIndianapolis | 24 - 21 | New England PatriotsNew England P |
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| 04 Dec 88 | r14        | New England PatriotsNew England P | 13 - 7 | Seattle SeahawksSeattle Seaha |
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| 11 Dec 88 | r15        | New England PatriotsNew England P | 10 - 7 | Tampa Bay BuccaneersTampa Bay Buc |
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| 17 Dec 88 | r16        | Denver BroncosDenver Bronco | 21 - 10 | New England PatriotsNew England P |