| 04 Sep 88 | r01        | Buffalo BillsBuffalo Bills | 13 - 10 | Minnesota VikingsMinnesota Vik |
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| 11 Sep 88 | r02        | Buffalo BillsBuffalo Bills | 9 - 6 | Miami DolphinsMiami Dolphin |
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| 18 Sep 88 | r03        | New England PatriotsNew England P | 14 - 16 | Buffalo BillsBuffalo Bills |
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| 25 Sep 88 | r04        | Buffalo BillsBuffalo Bills | 36 - 28 | Pittsburgh SteelersPittsburgh St |
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| 02 Oct 88 | r05        | Chicago BearsChicago Bears | 24 - 3 | Buffalo BillsBuffalo Bills |
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| 09 Oct 88 | r06        | Buffalo BillsBuffalo Bills | 34 - 23 | Indianapolis ColtsIndianapolis |
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| 18 Oct 88 | r07        | New York JetsNew York Jets | 14 - 37 | Buffalo BillsBuffalo Bills |
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| 23 Oct 88 | r08        | Buffalo BillsBuffalo Bills | 23 - 20 | New England PatriotsNew England P |
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| 30 Oct 88 | r09        | Buffalo BillsBuffalo Bills | 28 - 0 | Green Bay PackersGreen Bay Pac |
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| 06 Nov 88 | r10        | Seattle SeahawksSeattle Seaha | 3 - 13 | Buffalo BillsBuffalo Bills |
| 15 Nov 88 | r10        | Miami DolphinsMiami Dolphin | 6 - 31 | Buffalo BillsBuffalo Bills |
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| 20 Nov 88 | r12        | Buffalo BillsBuffalo Bills | 9 - 6 | New York JetsNew York Jets |
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| 27 Nov 88 | r13        | Cincinnati BengalsCincinnati Be | 35 - 21 | Buffalo BillsBuffalo Bills |
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| 04 Dec 88 | r14        | Tampa Bay BuccaneersTampa Bay Buc | 10 - 5 | Buffalo BillsBuffalo Bills |
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| 11 Dec 88 | r15        | Buffalo BillsBuffalo Bills | 37 - 21 | Las Vegas RaidersLas Vegas Rai |
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| 18 Dec 88 | r16        | Indianapolis ColtsIndianapolis | 17 - 14 | Buffalo BillsBuffalo Bills |
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| 01 Jan 89 | QF        | Buffalo BillsBuffalo Bills | 17 - 10 | Tennessee TitansTennessee Tit |
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| 08 Jan 89 | SF        | Cincinnati BengalsCincinnati Be | 21 - 10 | Buffalo BillsBuffalo Bills |