| 04 Dec 88 | r14        | Atlanta FalconsAtlanta Falco | 3 - 13 | San Francisco 49ersSan Francisco |
| 04 Dec 88 | r14        | Cincinnati BengalsCincinnati Be | 27 - 10 | Los Angeles ChargersLos Angeles C |
| 04 Dec 88 | r14        | Cleveland BrownsCleveland Bro | 24 - 21 | Dallas CowboysDallas Cowboy |
| 04 Dec 88 | r14        | Detroit LionsDetroit Lions | 30 - 14 | Green Bay PackersGreen Bay Pac |
| 04 Dec 88 | r14        | Miami DolphinsMiami Dolphin | 28 - 31 | Indianapolis ColtsIndianapolis |
| 04 Dec 88 | r14        | New England PatriotsNew England P | 13 - 7 | Seattle SeahawksSeattle Seaha |
| 04 Dec 88 | r14        | New York GiantsNew York Gian | 44 - 7 | Arizona CardinalsArizona Cardi |
| 04 Dec 88 | r14        | Philadelphia EaglesPhiladelphia | 19 - 20 | Washington CommandersWashington Co |
| 04 Dec 88 | r14        | Tampa Bay BuccaneersTampa Bay Buc | 10 - 5 | Buffalo BillsBuffalo Bills |
| 04 Dec 88 | r14        | Kansas City ChiefsKansas City C | 38 - 34 | New York JetsNew York Jets |
| 04 Dec 88 | r14        | Las Vegas RaidersLas Vegas Rai | 21 - 20 | Denver BroncosDenver Bronco |
| 04 Dec 88 | r14        | Minnesota VikingsMinnesota Vik | 45 - 3 | New Orleans SaintsNew Orleans S |
| 05 Dec 88 | r14        | Tennessee TitansTennessee Tit | 34 - 37 | Pittsburgh SteelersPittsburgh St |
| 06 Dec 88 | r14        | Los Angeles RamsLos Angeles R | 23 - 3 | Chicago BearsChicago Bears |