| 20 Nov 88 | r12        | Buffalo BillsBuffalo Bills | 9 - 6 | New York JetsNew York Jets |
| 20 Nov 88 | r12        | Cleveland BrownsCleveland Bro | 27 - 7 | Pittsburgh SteelersPittsburgh St |
| 20 Nov 88 | r12        | Dallas CowboysDallas Cowboy | 24 - 38 | Cincinnati BengalsCincinnati Be |
| 20 Nov 88 | r12        | Green Bay PackersGreen Bay Pac | 9 - 19 | Detroit LionsDetroit Lions |
| 20 Nov 88 | r12        | Kansas City ChiefsKansas City C | 27 - 24 | Seattle SeahawksSeattle Seaha |
| 20 Nov 88 | r12        | Minnesota VikingsMinnesota Vik | 12 - 3 | Indianapolis ColtsIndianapolis |
| 20 Nov 88 | r12        | Tampa Bay BuccaneersTampa Bay Buc | 15 - 27 | Chicago BearsChicago Bears |
| 20 Nov 88 | r12        | Tennessee TitansTennessee Tit | 38 - 20 | Arizona CardinalsArizona Cardi |
| 20 Nov 88 | r12        | Las Vegas RaidersLas Vegas Rai | 6 - 12 | Atlanta FalconsAtlanta Falco |
| 20 Nov 88 | r12        | Los Angeles RamsLos Angeles R | 24 - 38 | Los Angeles ChargersLos Angeles C |
| 20 Nov 88 | r12        | New Orleans SaintsNew Orleans S | 42 - 0 | Denver BroncosDenver Bronco |
| 20 Nov 88 | r12        | New York GiantsNew York Gian | 17 - 23 | Philadelphia EaglesPhiladelphia |
| 21 Nov 88 | r12        | Miami DolphinsMiami Dolphin | 3 - 6 | New England PatriotsNew England P |
| 22 Nov 88 | r12        | San Francisco 49ersSan Francisco | 37 - 21 | Washington CommandersWashington Co |