| 16 Oct 88 | r07        | Chicago BearsChicago Bears | 17 - 7 | Dallas CowboysDallas Cowboy |
| 16 Oct 88 | r07        | Indianapolis ColtsIndianapolis | 35 - 31 | Tampa Bay BuccaneersTampa Bay Buc |
| 16 Oct 88 | r07        | Kansas City ChiefsKansas City C | 17 - 27 | Las Vegas RaidersLas Vegas Rai |
| 16 Oct 88 | r07        | Minnesota VikingsMinnesota Vik | 14 - 34 | Green Bay PackersGreen Bay Pac |
| 16 Oct 88 | r07        | Cleveland BrownsCleveland Bro | 19 - 3 | Philadelphia EaglesPhiladelphia |
| 16 Oct 88 | r07        | New England PatriotsNew England P | 27 - 21 | Cincinnati BengalsCincinnati Be |
| 16 Oct 88 | r07        | New York GiantsNew York Gian | 30 - 10 | Detroit LionsDetroit Lions |
| 16 Oct 88 | r07        | Pittsburgh SteelersPittsburgh St | 14 - 34 | Tennessee TitansTennessee Tit |
| 16 Oct 88 | r07        | Washington CommandersWashington Co | 33 - 17 | Arizona CardinalsArizona Cardi |
| 16 Oct 88 | r07        | Denver BroncosDenver Bronco | 30 - 14 | Atlanta FalconsAtlanta Falco |
| 16 Oct 88 | r07        | Los Angeles RamsLos Angeles R | 21 - 24 | San Francisco 49ersSan Francisco |
| 16 Oct 88 | r07        | Miami DolphinsMiami Dolphin | 31 - 28 | Los Angeles ChargersLos Angeles C |
| 16 Oct 88 | r07        | Seattle SeahawksSeattle Seaha | 19 - 20 | New Orleans SaintsNew Orleans S |
| 18 Oct 88 | r07        | New York JetsNew York Jets | 14 - 37 | Buffalo BillsBuffalo Bills |