| 09 Oct 88 | r06        | Dallas CowboysDallas Cowboy | 17 - 35 | Washington CommandersWashington Co |
| 09 Oct 88 | r06        | Green Bay PackersGreen Bay Pac | 45 - 3 | New England PatriotsNew England P |
| 09 Oct 88 | r06        | Minnesota VikingsMinnesota Vik | 14 - 13 | Tampa Bay BuccaneersTampa Bay Buc |
| 09 Oct 88 | r06        | Tennessee TitansTennessee Tit | 7 - 6 | Kansas City ChiefsKansas City C |
| 09 Oct 88 | r06        | Atlanta FalconsAtlanta Falco | 0 - 33 | Los Angeles RamsLos Angeles R |
| 09 Oct 88 | r06        | Buffalo BillsBuffalo Bills | 34 - 23 | Indianapolis ColtsIndianapolis |
| 09 Oct 88 | r06        | Cincinnati BengalsCincinnati Be | 36 - 19 | New York JetsNew York Jets |
| 09 Oct 88 | r06        | Cleveland BrownsCleveland Bro | 10 - 16 | Seattle SeahawksSeattle Seaha |
| 09 Oct 88 | r06        | Detroit LionsDetroit Lions | 7 - 24 | Chicago BearsChicago Bears |
| 09 Oct 88 | r06        | Arizona CardinalsArizona Cardi | 31 - 14 | Pittsburgh SteelersPittsburgh St |
| 09 Oct 88 | r06        | Las Vegas RaidersLas Vegas Rai | 14 - 24 | Miami DolphinsMiami Dolphin |
| 09 Oct 88 | r06        | Los Angeles ChargersLos Angeles C | 17 - 23 | New Orleans SaintsNew Orleans S |
| 09 Oct 88 | r06        | San Francisco 49ersSan Francisco | 13 - 16 | Denver BroncosDenver Bronco |
| 11 Oct 88 | r06        | Philadelphia EaglesPhiladelphia | 24 - 13 | New York GiantsNew York Gian |