| 04 Sep 88 | r01        | Chicago BearsChicago Bears | 34 - 7 | Miami DolphinsMiami Dolphin |
| 04 Sep 88 | r01        | Green Bay PackersGreen Bay Pac | 7 - 34 | Los Angeles RamsLos Angeles R |
| 04 Sep 88 | r01        | New Orleans SaintsNew Orleans S | 33 - 34 | San Francisco 49ersSan Francisco |
| 04 Sep 88 | r01        | Buffalo BillsBuffalo Bills | 13 - 10 | Minnesota VikingsMinnesota Vik |
| 04 Sep 88 | r01        | Cincinnati BengalsCincinnati Be | 21 - 14 | Arizona CardinalsArizona Cardi |
| 04 Sep 88 | r01        | Detroit LionsDetroit Lions | 31 - 17 | Atlanta FalconsAtlanta Falco |
| 04 Sep 88 | r01        | Pittsburgh SteelersPittsburgh St | 24 - 21 | Dallas CowboysDallas Cowboy |
| 04 Sep 88 | r01        | Tampa Bay BuccaneersTampa Bay Buc | 14 - 41 | Philadelphia EaglesPhiladelphia |
| 04 Sep 88 | r01        | Denver BroncosDenver Bronco | 14 - 21 | Seattle SeahawksSeattle Seaha |
| 04 Sep 88 | r01        | Indianapolis ColtsIndianapolis | 14 - 17 | Tennessee TitansTennessee Tit |
| 04 Sep 88 | r01        | Kansas City ChiefsKansas City C | 3 - 6 | Cleveland BrownsCleveland Bro |
| 04 Sep 88 | r01        | Las Vegas RaidersLas Vegas Rai | 24 - 13 | Los Angeles ChargersLos Angeles C |
| 04 Sep 88 | r01        | New England PatriotsNew England P | 28 - 3 | New York JetsNew York Jets |
| 06 Sep 88 | r01        | New York GiantsNew York Gian | 27 - 20 | Washington CommandersWashington Co |