| 08 Sep 81 | r01        | Cleveland BrownsCleveland Bro | 14 - 44 | Los Angeles ChargersLos Angeles C |
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| 13 Sep 81 | r02        | Cleveland BrownsCleveland Bro | 3 - 9 | Tennessee TitansTennessee Tit |
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| 20 Sep 81 | r03        | Cincinnati BengalsCincinnati Be | 17 - 20 | Cleveland BrownsCleveland Bro |
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| 27 Sep 81 | r04        | Cleveland BrownsCleveland Bro | 28 - 17 | Atlanta FalconsAtlanta Falco |
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| 04 Oct 81 | r05        | Los Angeles RamsLos Angeles R | 27 - 16 | Cleveland BrownsCleveland Bro |
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| 11 Oct 81 | r06        | Pittsburgh SteelersPittsburgh St | 13 - 7 | Cleveland BrownsCleveland Bro |
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| 18 Oct 81 | r07        | Cleveland BrownsCleveland Bro | 20 - 17 | New Orleans SaintsNew Orleans S |
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| 25 Oct 81 | r08        | Cleveland BrownsCleveland Bro | 42 - 28 | Indianapolis ColtsIndianapolis |
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| 01 Nov 81 | r09        | Buffalo BillsBuffalo Bills | 22 - 13 | Cleveland BrownsCleveland Bro |
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| 08 Nov 81 | r10        | Denver BroncosDenver Bronco | 23 - 20 | Cleveland BrownsCleveland Bro |
| 15 Nov 81 | r10        | San Francisco 49ersSan Francisco | 12 - 15 | Cleveland BrownsCleveland Bro |
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| 22 Nov 81 | r12        | Cleveland BrownsCleveland Bro | 10 - 32 | Pittsburgh SteelersPittsburgh St |
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| 29 Nov 81 | r13        | Cleveland BrownsCleveland Bro | 21 - 41 | Cincinnati BengalsCincinnati Be |
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| 04 Dec 81 | r14        | Tennessee TitansTennessee Tit | 17 - 13 | Cleveland BrownsCleveland Bro |
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| 12 Dec 81 | r15        | Cleveland BrownsCleveland Bro | 13 - 14 | New York JetsNew York Jets |
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| 20 Dec 81 | r16        | Seattle SeahawksSeattle Seaha | 42 - 21 | Cleveland BrownsCleveland Bro |