| 07 Sep 80 | r01        | Los Angeles RamsLos Angeles R | 20 - 41 | Detroit LionsDetroit Lions |
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| 12 Sep 80 | r02        | Tampa Bay BuccaneersTampa Bay Buc | 10 - 9 | Los Angeles RamsLos Angeles R |
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| 21 Sep 80 | r03        | Los Angeles RamsLos Angeles R | 51 - 21 | Green Bay PackersGreen Bay Pac |
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| 28 Sep 80 | r04        | New York GiantsNew York Gian | 7 - 28 | Los Angeles RamsLos Angeles R |
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| 05 Oct 80 | r05        | Los Angeles RamsLos Angeles R | 48 - 26 | San Francisco 49ersSan Francisco |
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| 12 Oct 80 | r06        | Arizona CardinalsArizona Cardi | 13 - 21 | Los Angeles RamsLos Angeles R |
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| 19 Oct 80 | r07        | San Francisco 49ersSan Francisco | 17 - 31 | Los Angeles RamsLos Angeles R |
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| 26 Oct 80 | r08        | Atlanta FalconsAtlanta Falco | 13 - 10 | Los Angeles RamsLos Angeles R |
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| 02 Nov 80 | r09        | Los Angeles RamsLos Angeles R | 45 - 31 | New Orleans SaintsNew Orleans S |
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| 09 Nov 80 | r10        | Los Angeles RamsLos Angeles R | 14 - 35 | Miami DolphinsMiami Dolphin |
| 16 Nov 80 | r10        | New England PatriotsNew England P | 14 - 17 | Los Angeles RamsLos Angeles R |
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| 25 Nov 80 | r12        | New Orleans SaintsNew Orleans S | 7 - 27 | Los Angeles RamsLos Angeles R |
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| 30 Nov 80 | r13        | Los Angeles RamsLos Angeles R | 38 - 13 | New York JetsNew York Jets |
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| 07 Dec 80 | r14        | Buffalo BillsBuffalo Bills | 10 - 7 | Los Angeles RamsLos Angeles R |
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| 16 Dec 80 | r15        | Los Angeles RamsLos Angeles R | 38 - 14 | Dallas CowboysDallas Cowboy |
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| 21 Dec 80 | r16        | Los Angeles RamsLos Angeles R | 20 - 17 | Atlanta FalconsAtlanta Falco |
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| 28 Dec 80 | Playoff        | Dallas CowboysDallas Cowboy | 34 - 13 | Los Angeles RamsLos Angeles R |