| 07 Sep 80 | r01        | Arizona CardinalsArizona Cardi | 35 - 41 | New York GiantsNew York Gian |
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| 14 Sep 80 | r02        | San Francisco 49ersSan Francisco | 24 - 21 | Arizona CardinalsArizona Cardi |
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| 21 Sep 80 | r03        | Detroit LionsDetroit Lions | 20 - 7 | Arizona CardinalsArizona Cardi |
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| 28 Sep 80 | r04        | Arizona CardinalsArizona Cardi | 24 - 14 | Philadelphia EaglesPhiladelphia |
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| 05 Oct 80 | r05        | New Orleans SaintsNew Orleans S | 7 - 40 | Arizona CardinalsArizona Cardi |
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| 12 Oct 80 | r06        | Arizona CardinalsArizona Cardi | 13 - 21 | Los Angeles RamsLos Angeles R |
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| 19 Oct 80 | r07        | Washington CommandersWashington Co | 23 - 0 | Arizona CardinalsArizona Cardi |
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| 26 Oct 80 | r08        | Indianapolis ColtsIndianapolis | 10 - 17 | Arizona CardinalsArizona Cardi |
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| 02 Nov 80 | r09        | Arizona CardinalsArizona Cardi | 24 - 27 | Dallas CowboysDallas Cowboy |
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| 09 Nov 80 | r10        | Arizona CardinalsArizona Cardi | 27 - 33 | Atlanta FalconsAtlanta Falco |
| 16 Nov 80 | r10        | Dallas CowboysDallas Cowboy | 31 - 21 | Arizona CardinalsArizona Cardi |
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| 23 Nov 80 | r12        | Arizona CardinalsArizona Cardi | 13 - 21 | Kansas City ChiefsKansas City C |
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| 30 Nov 80 | r13        | New York GiantsNew York Gian | 7 - 23 | Arizona CardinalsArizona Cardi |
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| 07 Dec 80 | r14        | Arizona CardinalsArizona Cardi | 24 - 23 | Detroit LionsDetroit Lions |
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| 14 Dec 80 | r15        | Philadelphia EaglesPhiladelphia | 17 - 3 | Arizona CardinalsArizona Cardi |
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| 21 Dec 80 | r16        | Arizona CardinalsArizona Cardi | 7 - 31 | Washington CommandersWashington Co |