| 07 Sep 80 | r01        | Cincinnati BengalsCincinnati Be | 12 - 17 | Tampa Bay BuccaneersTampa Bay Buc |
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| 12 Sep 80 | r02        | Tampa Bay BuccaneersTampa Bay Buc | 10 - 9 | Los Angeles RamsLos Angeles R |
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| 21 Sep 80 | r03        | Dallas CowboysDallas Cowboy | 28 - 17 | Tampa Bay BuccaneersTampa Bay Buc |
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| 28 Sep 80 | r04        | Tampa Bay BuccaneersTampa Bay Buc | 27 - 34 | Cleveland BrownsCleveland Bro |
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| 07 Oct 80 | r05        | Chicago BearsChicago Bears | 23 - 0 | Tampa Bay BuccaneersTampa Bay Buc |
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| 12 Oct 80 | r06        | Tampa Bay BuccaneersTampa Bay Buc | 14 - 14 | Green Bay PackersGreen Bay Pac |
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| 19 Oct 80 | r07        | Tennessee TitansTennessee Tit | 20 - 14 | Tampa Bay BuccaneersTampa Bay Buc |
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| 26 Oct 80 | r08        | San Francisco 49ersSan Francisco | 23 - 24 | Tampa Bay BuccaneersTampa Bay Buc |
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| 02 Nov 80 | r09        | Tampa Bay BuccaneersTampa Bay Buc | 30 - 13 | New York GiantsNew York Gian |
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| 09 Nov 80 | r10        | Tampa Bay BuccaneersTampa Bay Buc | 21 - 24 | Pittsburgh SteelersPittsburgh St |
| 16 Nov 80 | r10        | Minnesota VikingsMinnesota Vik | 38 - 30 | Tampa Bay BuccaneersTampa Bay Buc |
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| 23 Nov 80 | r12        | Tampa Bay BuccaneersTampa Bay Buc | 10 - 24 | Detroit LionsDetroit Lions |
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| 30 Nov 80 | r13        | Green Bay PackersGreen Bay Pac | 17 - 20 | Tampa Bay BuccaneersTampa Bay Buc |
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| 07 Dec 80 | r14        | Tampa Bay BuccaneersTampa Bay Buc | 10 - 21 | Minnesota VikingsMinnesota Vik |
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| 14 Dec 80 | r15        | Detroit LionsDetroit Lions | 27 - 14 | Tampa Bay BuccaneersTampa Bay Buc |
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| 20 Dec 80 | r16        | Tampa Bay BuccaneersTampa Bay Buc | 13 - 14 | Chicago BearsChicago Bears |