| 07 Sep 80 | r01        | New Orleans SaintsNew Orleans S | 23 - 26 | San Francisco 49ersSan Francisco |
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| 14 Sep 80 | r02        | Chicago BearsChicago Bears | 22 - 3 | New Orleans SaintsNew Orleans S |
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| 21 Sep 80 | r03        | New Orleans SaintsNew Orleans S | 26 - 35 | Buffalo BillsBuffalo Bills |
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| 28 Sep 80 | r04        | Miami DolphinsMiami Dolphin | 21 - 16 | New Orleans SaintsNew Orleans S |
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| 05 Oct 80 | r05        | New Orleans SaintsNew Orleans S | 7 - 40 | Arizona CardinalsArizona Cardi |
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| 12 Oct 80 | r06        | Detroit LionsDetroit Lions | 24 - 13 | New Orleans SaintsNew Orleans S |
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| 19 Oct 80 | r07        | New Orleans SaintsNew Orleans S | 14 - 41 | Atlanta FalconsAtlanta Falco |
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| 26 Oct 80 | r08        | Washington CommandersWashington Co | 22 - 14 | New Orleans SaintsNew Orleans S |
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| 02 Nov 80 | r09        | Los Angeles RamsLos Angeles R | 45 - 31 | New Orleans SaintsNew Orleans S |
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| 09 Nov 80 | r10        | New Orleans SaintsNew Orleans S | 21 - 34 | Philadelphia EaglesPhiladelphia |
| 16 Nov 80 | r10        | Atlanta FalconsAtlanta Falco | 31 - 13 | New Orleans SaintsNew Orleans S |
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| 25 Nov 80 | r12        | New Orleans SaintsNew Orleans S | 7 - 27 | Los Angeles RamsLos Angeles R |
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| 30 Nov 80 | r13        | New Orleans SaintsNew Orleans S | 20 - 23 | Minnesota VikingsMinnesota Vik |
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| 07 Dec 80 | r14        | San Francisco 49ersSan Francisco | 38 - 35 | New Orleans SaintsNew Orleans S |
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| 14 Dec 80 | r15        | New York JetsNew York Jets | 20 - 21 | New Orleans SaintsNew Orleans S |
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| 21 Dec 80 | r16        | New Orleans SaintsNew Orleans S | 27 - 38 | New England PatriotsNew England P |