| 07 Sep 80 | r01        | Minnesota VikingsMinnesota Vik | 24 - 23 | Atlanta FalconsAtlanta Falco |
| |
| 14 Sep 80 | r02        | Minnesota VikingsMinnesota Vik | 7 - 42 | Philadelphia EaglesPhiladelphia |
| |
| 21 Sep 80 | r03        | Chicago BearsChicago Bears | 14 - 34 | Minnesota VikingsMinnesota Vik |
| |
| 28 Sep 80 | r04        | Detroit LionsDetroit Lions | 27 - 7 | Minnesota VikingsMinnesota Vik |
| |
| 05 Oct 80 | r05        | Minnesota VikingsMinnesota Vik | 17 - 23 | Pittsburgh SteelersPittsburgh St |
| |
| 12 Oct 80 | r06        | Minnesota VikingsMinnesota Vik | 13 - 7 | Chicago BearsChicago Bears |
| |
| 19 Oct 80 | r07        | Cincinnati BengalsCincinnati Be | 14 - 0 | Minnesota VikingsMinnesota Vik |
| |
| 26 Oct 80 | r08        | Green Bay PackersGreen Bay Pac | 16 - 3 | Minnesota VikingsMinnesota Vik |
| |
| 02 Nov 80 | r09        | Washington CommandersWashington Co | 14 - 39 | Minnesota VikingsMinnesota Vik |
| |
| 09 Nov 80 | r10        | Minnesota VikingsMinnesota Vik | 34 - 0 | Detroit LionsDetroit Lions |
| 16 Nov 80 | r10        | Minnesota VikingsMinnesota Vik | 38 - 30 | Tampa Bay BuccaneersTampa Bay Buc |
| |
| 23 Nov 80 | r12        | Minnesota VikingsMinnesota Vik | 13 - 25 | Green Bay PackersGreen Bay Pac |
| |
| 30 Nov 80 | r13        | New Orleans SaintsNew Orleans S | 20 - 23 | Minnesota VikingsMinnesota Vik |
| |
| 07 Dec 80 | r14        | Tampa Bay BuccaneersTampa Bay Buc | 10 - 21 | Minnesota VikingsMinnesota Vik |
| |
| 14 Dec 80 | r15        | Minnesota VikingsMinnesota Vik | 28 - 23 | Cleveland BrownsCleveland Bro |
| |
| 21 Dec 80 | r16        | Tennessee TitansTennessee Tit | 20 - 16 | Minnesota VikingsMinnesota Vik |
| |
| 03 Jan 81 | QF        | Philadelphia EaglesPhiladelphia | 31 - 16 | Minnesota VikingsMinnesota Vik |