| 07 Sep 80 | r01        | Green Bay PackersGreen Bay Pac | 12 - 6 | Chicago BearsChicago Bears |
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| 14 Sep 80 | r02        | Green Bay PackersGreen Bay Pac | 7 - 29 | Detroit LionsDetroit Lions |
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| 21 Sep 80 | r03        | Los Angeles RamsLos Angeles R | 51 - 21 | Green Bay PackersGreen Bay Pac |
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| 28 Sep 80 | r04        | Green Bay PackersGreen Bay Pac | 7 - 28 | Dallas CowboysDallas Cowboy |
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| 05 Oct 80 | r05        | Green Bay PackersGreen Bay Pac | 14 - 9 | Cincinnati BengalsCincinnati Be |
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| 12 Oct 80 | r06        | Tampa Bay BuccaneersTampa Bay Buc | 14 - 14 | Green Bay PackersGreen Bay Pac |
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| 19 Oct 80 | r07        | Cleveland BrownsCleveland Bro | 26 - 21 | Green Bay PackersGreen Bay Pac |
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| 26 Oct 80 | r08        | Green Bay PackersGreen Bay Pac | 16 - 3 | Minnesota VikingsMinnesota Vik |
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| 02 Nov 80 | r09        | Pittsburgh SteelersPittsburgh St | 22 - 20 | Green Bay PackersGreen Bay Pac |
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| 09 Nov 80 | r10        | Green Bay PackersGreen Bay Pac | 23 - 16 | San Francisco 49ersSan Francisco |
| 16 Nov 80 | r10        | New York GiantsNew York Gian | 27 - 21 | Green Bay PackersGreen Bay Pac |
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| 23 Nov 80 | r12        | Minnesota VikingsMinnesota Vik | 13 - 25 | Green Bay PackersGreen Bay Pac |
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| 30 Nov 80 | r13        | Green Bay PackersGreen Bay Pac | 17 - 20 | Tampa Bay BuccaneersTampa Bay Buc |
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| 07 Dec 80 | r14        | Chicago BearsChicago Bears | 61 - 7 | Green Bay PackersGreen Bay Pac |
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| 14 Dec 80 | r15        | Green Bay PackersGreen Bay Pac | 3 - 22 | Tennessee TitansTennessee Tit |
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| 21 Dec 80 | r16        | Detroit LionsDetroit Lions | 24 - 3 | Green Bay PackersGreen Bay Pac |