| 07 Sep 80 | r01        | Los Angeles RamsLos Angeles R | 20 - 41 | Detroit LionsDetroit Lions |
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| 14 Sep 80 | r02        | Green Bay PackersGreen Bay Pac | 7 - 29 | Detroit LionsDetroit Lions |
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| 21 Sep 80 | r03        | Detroit LionsDetroit Lions | 20 - 7 | Arizona CardinalsArizona Cardi |
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| 28 Sep 80 | r04        | Detroit LionsDetroit Lions | 27 - 7 | Minnesota VikingsMinnesota Vik |
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| 05 Oct 80 | r05        | Atlanta FalconsAtlanta Falco | 43 - 28 | Detroit LionsDetroit Lions |
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| 12 Oct 80 | r06        | Detroit LionsDetroit Lions | 24 - 13 | New Orleans SaintsNew Orleans S |
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| 19 Oct 80 | r07        | Chicago BearsChicago Bears | 24 - 7 | Detroit LionsDetroit Lions |
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| 26 Oct 80 | r08        | Kansas City ChiefsKansas City C | 20 - 17 | Detroit LionsDetroit Lions |
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| 02 Nov 80 | r09        | Detroit LionsDetroit Lions | 17 - 13 | San Francisco 49ersSan Francisco |
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| 09 Nov 80 | r10        | Minnesota VikingsMinnesota Vik | 34 - 0 | Detroit LionsDetroit Lions |
| 16 Nov 80 | r10        | Detroit LionsDetroit Lions | 9 - 10 | Indianapolis ColtsIndianapolis |
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| 23 Nov 80 | r12        | Tampa Bay BuccaneersTampa Bay Buc | 10 - 24 | Detroit LionsDetroit Lions |
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| 27 Nov 80 | r13        | Detroit LionsDetroit Lions | 17 - 23 | Chicago BearsChicago Bears |
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| 07 Dec 80 | r14        | Arizona CardinalsArizona Cardi | 24 - 23 | Detroit LionsDetroit Lions |
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| 14 Dec 80 | r15        | Detroit LionsDetroit Lions | 27 - 14 | Tampa Bay BuccaneersTampa Bay Buc |
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| 21 Dec 80 | r16        | Detroit LionsDetroit Lions | 24 - 3 | Green Bay PackersGreen Bay Pac |