| 07 Sep 80 | r01        | Green Bay PackersGreen Bay Pac | 12 - 6 | Chicago BearsChicago Bears |
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| 14 Sep 80 | r02        | Chicago BearsChicago Bears | 22 - 3 | New Orleans SaintsNew Orleans S |
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| 21 Sep 80 | r03        | Chicago BearsChicago Bears | 14 - 34 | Minnesota VikingsMinnesota Vik |
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| 28 Sep 80 | r04        | Pittsburgh SteelersPittsburgh St | 38 - 3 | Chicago BearsChicago Bears |
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| 07 Oct 80 | r05        | Chicago BearsChicago Bears | 23 - 0 | Tampa Bay BuccaneersTampa Bay Buc |
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| 12 Oct 80 | r06        | Minnesota VikingsMinnesota Vik | 13 - 7 | Chicago BearsChicago Bears |
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| 19 Oct 80 | r07        | Chicago BearsChicago Bears | 24 - 7 | Detroit LionsDetroit Lions |
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| 26 Oct 80 | r08        | Philadelphia EaglesPhiladelphia | 17 - 14 | Chicago BearsChicago Bears |
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| 04 Nov 80 | r09        | Cleveland BrownsCleveland Bro | 27 - 21 | Chicago BearsChicago Bears |
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| 09 Nov 80 | r10        | Chicago BearsChicago Bears | 35 - 21 | Washington CommandersWashington Co |
| 16 Nov 80 | r10        | Chicago BearsChicago Bears | 6 - 10 | Tennessee TitansTennessee Tit |
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| 23 Nov 80 | r12        | Atlanta FalconsAtlanta Falco | 28 - 17 | Chicago BearsChicago Bears |
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| 27 Nov 80 | r13        | Detroit LionsDetroit Lions | 17 - 23 | Chicago BearsChicago Bears |
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| 07 Dec 80 | r14        | Chicago BearsChicago Bears | 61 - 7 | Green Bay PackersGreen Bay Pac |
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| 14 Dec 80 | r15        | Chicago BearsChicago Bears | 14 - 17 | Cincinnati BengalsCincinnati Be |
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| 20 Dec 80 | r16        | Tampa Bay BuccaneersTampa Bay Buc | 13 - 14 | Chicago BearsChicago Bears |