| 07 Sep 80 | r01        | New York JetsNew York Jets | 14 - 17 | Indianapolis ColtsIndianapolis |
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| 14 Sep 80 | r02        | Indianapolis ColtsIndianapolis | 17 - 20 | Pittsburgh SteelersPittsburgh St |
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| 21 Sep 80 | r03        | Tennessee TitansTennessee Tit | 21 - 16 | Indianapolis ColtsIndianapolis |
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| 28 Sep 80 | r04        | Indianapolis ColtsIndianapolis | 35 - 21 | New York JetsNew York Jets |
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| 05 Oct 80 | r05        | Miami DolphinsMiami Dolphin | 17 - 30 | Indianapolis ColtsIndianapolis |
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| 12 Oct 80 | r06        | Buffalo BillsBuffalo Bills | 12 - 17 | Indianapolis ColtsIndianapolis |
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| 19 Oct 80 | r07        | Indianapolis ColtsIndianapolis | 21 - 37 | New England PatriotsNew England P |
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| 26 Oct 80 | r08        | Indianapolis ColtsIndianapolis | 10 - 17 | Arizona CardinalsArizona Cardi |
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| 02 Nov 80 | r09        | Kansas City ChiefsKansas City C | 24 - 31 | Indianapolis ColtsIndianapolis |
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| 09 Nov 80 | r10        | Indianapolis ColtsIndianapolis | 27 - 28 | Cleveland BrownsCleveland Bro |
| 16 Nov 80 | r10        | Detroit LionsDetroit Lions | 9 - 10 | Indianapolis ColtsIndianapolis |
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| 23 Nov 80 | r12        | New England PatriotsNew England P | 47 - 21 | Indianapolis ColtsIndianapolis |
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| 30 Nov 80 | r13        | Indianapolis ColtsIndianapolis | 28 - 24 | Buffalo BillsBuffalo Bills |
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| 07 Dec 80 | r14        | Cincinnati BengalsCincinnati Be | 34 - 33 | Indianapolis ColtsIndianapolis |
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| 14 Dec 80 | r15        | Indianapolis ColtsIndianapolis | 14 - 24 | Miami DolphinsMiami Dolphin |
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| 21 Dec 80 | r16        | Indianapolis ColtsIndianapolis | 28 - 38 | Kansas City ChiefsKansas City C |