| 07 Sep 80 | r01        | Pittsburgh SteelersPittsburgh St | 31 - 17 | Tennessee TitansTennessee Tit |
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| 14 Sep 80 | r02        | Indianapolis ColtsIndianapolis | 17 - 20 | Pittsburgh SteelersPittsburgh St |
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| 21 Sep 80 | r03        | Cincinnati BengalsCincinnati Be | 30 - 28 | Pittsburgh SteelersPittsburgh St |
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| 28 Sep 80 | r04        | Pittsburgh SteelersPittsburgh St | 38 - 3 | Chicago BearsChicago Bears |
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| 05 Oct 80 | r05        | Minnesota VikingsMinnesota Vik | 17 - 23 | Pittsburgh SteelersPittsburgh St |
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| 12 Oct 80 | r06        | Pittsburgh SteelersPittsburgh St | 16 - 17 | Cincinnati BengalsCincinnati Be |
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| 21 Oct 80 | r07        | Pittsburgh SteelersPittsburgh St | 34 - 45 | Las Vegas RaidersLas Vegas Rai |
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| 26 Oct 80 | r08        | Cleveland BrownsCleveland Bro | 27 - 26 | Pittsburgh SteelersPittsburgh St |
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| 02 Nov 80 | r09        | Pittsburgh SteelersPittsburgh St | 22 - 20 | Green Bay PackersGreen Bay Pac |
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| 09 Nov 80 | r10        | Tampa Bay BuccaneersTampa Bay Buc | 21 - 24 | Pittsburgh SteelersPittsburgh St |
| 16 Nov 80 | r10        | Pittsburgh SteelersPittsburgh St | 16 - 13 | Cleveland BrownsCleveland Bro |
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| 23 Nov 80 | r12        | Buffalo BillsBuffalo Bills | 28 - 13 | Pittsburgh SteelersPittsburgh St |
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| 30 Nov 80 | r13        | Pittsburgh SteelersPittsburgh St | 23 - 10 | Miami DolphinsMiami Dolphin |
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| 05 Dec 80 | r14        | Tennessee TitansTennessee Tit | 6 - 0 | Pittsburgh SteelersPittsburgh St |
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| 14 Dec 80 | r15        | Pittsburgh SteelersPittsburgh St | 21 - 16 | Kansas City ChiefsKansas City C |
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| 23 Dec 80 | r16        | Los Angeles ChargersLos Angeles C | 26 - 17 | Pittsburgh SteelersPittsburgh St |