| 07 Sep 80 | r01        | Cincinnati BengalsCincinnati Be | 12 - 17 | Tampa Bay BuccaneersTampa Bay Buc |
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| 14 Sep 80 | r02        | Miami DolphinsMiami Dolphin | 17 - 16 | Cincinnati BengalsCincinnati Be |
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| 21 Sep 80 | r03        | Cincinnati BengalsCincinnati Be | 30 - 28 | Pittsburgh SteelersPittsburgh St |
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| 28 Sep 80 | r04        | Cincinnati BengalsCincinnati Be | 10 - 13 | Tennessee TitansTennessee Tit |
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| 05 Oct 80 | r05        | Green Bay PackersGreen Bay Pac | 14 - 9 | Cincinnati BengalsCincinnati Be |
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| 12 Oct 80 | r06        | Pittsburgh SteelersPittsburgh St | 16 - 17 | Cincinnati BengalsCincinnati Be |
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| 19 Oct 80 | r07        | Cincinnati BengalsCincinnati Be | 14 - 0 | Minnesota VikingsMinnesota Vik |
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| 26 Oct 80 | r08        | Tennessee TitansTennessee Tit | 23 - 3 | Cincinnati BengalsCincinnati Be |
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| 02 Nov 80 | r09        | Cincinnati BengalsCincinnati Be | 14 - 31 | Los Angeles ChargersLos Angeles C |
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| 09 Nov 80 | r10        | Las Vegas RaidersLas Vegas Rai | 28 - 17 | Cincinnati BengalsCincinnati Be |
| 16 Nov 80 | r10        | Cincinnati BengalsCincinnati Be | 0 - 14 | Buffalo BillsBuffalo Bills |
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| 23 Nov 80 | r12        | Cleveland BrownsCleveland Bro | 31 - 7 | Cincinnati BengalsCincinnati Be |
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| 30 Nov 80 | r13        | Kansas City ChiefsKansas City C | 6 - 20 | Cincinnati BengalsCincinnati Be |
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| 07 Dec 80 | r14        | Cincinnati BengalsCincinnati Be | 34 - 33 | Indianapolis ColtsIndianapolis |
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| 14 Dec 80 | r15        | Chicago BearsChicago Bears | 14 - 17 | Cincinnati BengalsCincinnati Be |
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| 21 Dec 80 | r16        | Cincinnati BengalsCincinnati Be | 24 - 27 | Cleveland BrownsCleveland Bro |