| 07 Sep 80 | r01        | New England PatriotsNew England P | 34 - 17 | Cleveland BrownsCleveland Bro |
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| 14 Sep 80 | r02        | New England PatriotsNew England P | 21 - 37 | Atlanta FalconsAtlanta Falco |
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| 21 Sep 80 | r03        | Seattle SeahawksSeattle Seaha | 31 - 37 | New England PatriotsNew England P |
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| 30 Sep 80 | r04        | New England PatriotsNew England P | 23 - 14 | Denver BroncosDenver Bronco |
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| 05 Oct 80 | r05        | New York JetsNew York Jets | 11 - 21 | New England PatriotsNew England P |
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| 12 Oct 80 | r06        | New England PatriotsNew England P | 34 - 0 | Miami DolphinsMiami Dolphin |
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| 19 Oct 80 | r07        | Indianapolis ColtsIndianapolis | 21 - 37 | New England PatriotsNew England P |
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| 26 Oct 80 | r08        | Buffalo BillsBuffalo Bills | 31 - 13 | New England PatriotsNew England P |
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| 02 Nov 80 | r09        | New England PatriotsNew England P | 34 - 21 | New York JetsNew York Jets |
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| 11 Nov 80 | r10        | Tennessee TitansTennessee Tit | 38 - 34 | New England PatriotsNew England P |
| 16 Nov 80 | r10        | New England PatriotsNew England P | 14 - 17 | Los Angeles RamsLos Angeles R |
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| 23 Nov 80 | r12        | New England PatriotsNew England P | 47 - 21 | Indianapolis ColtsIndianapolis |
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| 30 Nov 80 | r13        | San Francisco 49ersSan Francisco | 21 - 17 | New England PatriotsNew England P |
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| 09 Dec 80 | r14        | Miami DolphinsMiami Dolphin | 16 - 13 | New England PatriotsNew England P |
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| 14 Dec 80 | r15        | New England PatriotsNew England P | 24 - 2 | Buffalo BillsBuffalo Bills |
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| 21 Dec 80 | r16        | New Orleans SaintsNew Orleans S | 27 - 38 | New England PatriotsNew England P |