| 07 Sep 80 | r01        | Buffalo BillsBuffalo Bills | 17 - 7 | Miami DolphinsMiami Dolphin |
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| 14 Sep 80 | r02        | Miami DolphinsMiami Dolphin | 17 - 16 | Cincinnati BengalsCincinnati Be |
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| 21 Sep 80 | r03        | Atlanta FalconsAtlanta Falco | 17 - 20 | Miami DolphinsMiami Dolphin |
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| 28 Sep 80 | r04        | Miami DolphinsMiami Dolphin | 21 - 16 | New Orleans SaintsNew Orleans S |
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| 05 Oct 80 | r05        | Miami DolphinsMiami Dolphin | 17 - 30 | Indianapolis ColtsIndianapolis |
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| 12 Oct 80 | r06        | New England PatriotsNew England P | 34 - 0 | Miami DolphinsMiami Dolphin |
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| 19 Oct 80 | r07        | Miami DolphinsMiami Dolphin | 17 - 14 | Buffalo BillsBuffalo Bills |
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| 28 Oct 80 | r08        | New York JetsNew York Jets | 17 - 14 | Miami DolphinsMiami Dolphin |
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| 02 Nov 80 | r09        | Las Vegas RaidersLas Vegas Rai | 16 - 10 | Miami DolphinsMiami Dolphin |
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| 09 Nov 80 | r10        | Los Angeles RamsLos Angeles R | 14 - 35 | Miami DolphinsMiami Dolphin |
| 16 Nov 80 | r10        | Miami DolphinsMiami Dolphin | 17 - 13 | San Francisco 49ersSan Francisco |
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| 21 Nov 80 | r12        | Miami DolphinsMiami Dolphin | 24 - 27 | Los Angeles ChargersLos Angeles C |
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| 30 Nov 80 | r13        | Pittsburgh SteelersPittsburgh St | 23 - 10 | Miami DolphinsMiami Dolphin |
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| 09 Dec 80 | r14        | Miami DolphinsMiami Dolphin | 16 - 13 | New England PatriotsNew England P |
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| 14 Dec 80 | r15        | Indianapolis ColtsIndianapolis | 14 - 24 | Miami DolphinsMiami Dolphin |
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| 20 Dec 80 | r16        | Miami DolphinsMiami Dolphin | 17 - 24 | New York JetsNew York Jets |