| 03 Sep 78 | r01        | Tampa Bay BuccaneersTampa Bay Buc | 13 - 19 | New York GiantsNew York Gian |
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| 10 Sep 78 | r02        | New York GiantsNew York Gian | 24 - 34 | Dallas CowboysDallas Cowboy |
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| 17 Sep 78 | r03        | New York GiantsNew York Gian | 26 - 10 | Kansas City ChiefsKansas City C |
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| 24 Sep 78 | r04        | New York GiantsNew York Gian | 27 - 10 | San Francisco 49ersSan Francisco |
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| 01 Oct 78 | r05        | Atlanta FalconsAtlanta Falco | 23 - 20 | New York GiantsNew York Gian |
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| 08 Oct 78 | r06        | Dallas CowboysDallas Cowboy | 24 - 3 | New York GiantsNew York Gian |
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| 15 Oct 78 | r07        | New York GiantsNew York Gian | 17 - 14 | Tampa Bay BuccaneersTampa Bay Buc |
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| 22 Oct 78 | r08        | New York GiantsNew York Gian | 17 - 6 | Washington CommandersWashington Co |
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| 29 Oct 78 | r09        | New Orleans SaintsNew Orleans S | 28 - 17 | New York GiantsNew York Gian |
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| 05 Nov 78 | r10        | Arizona CardinalsArizona Cardi | 20 - 10 | New York GiantsNew York Gian |
| 12 Nov 78 | r10        | Washington CommandersWashington Co | 16 - 13 | New York GiantsNew York Gian |
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| 19 Nov 78 | r12        | New York GiantsNew York Gian | 17 - 19 | Philadelphia EaglesPhiladelphia |
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| 26 Nov 78 | r13        | Buffalo BillsBuffalo Bills | 41 - 17 | New York GiantsNew York Gian |
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| 03 Dec 78 | r14        | New York GiantsNew York Gian | 17 - 20 | Los Angeles RamsLos Angeles R |
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| 10 Dec 78 | r15        | New York GiantsNew York Gian | 17 - 0 | Arizona CardinalsArizona Cardi |
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| 17 Dec 78 | r16        | Philadelphia EaglesPhiladelphia | 20 - 3 | New York GiantsNew York Gian |