| 03 Sep 78 | r01        | Cleveland BrownsCleveland Bro | 24 - 7 | San Francisco 49ersSan Francisco |
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| 10 Sep 78 | r02        | Cleveland BrownsCleveland Bro | 13 - 10 | Cincinnati BengalsCincinnati Be |
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| 17 Sep 78 | r03        | Atlanta FalconsAtlanta Falco | 16 - 24 | Cleveland BrownsCleveland Bro |
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| 24 Sep 78 | r04        | Pittsburgh SteelersPittsburgh St | 15 - 9 | Cleveland BrownsCleveland Bro |
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| 01 Oct 78 | r05        | Cleveland BrownsCleveland Bro | 13 - 16 | Tennessee TitansTennessee Tit |
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| 08 Oct 78 | r06        | New Orleans SaintsNew Orleans S | 16 - 24 | Cleveland BrownsCleveland Bro |
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| 15 Oct 78 | r07        | Cleveland BrownsCleveland Bro | 14 - 34 | Pittsburgh SteelersPittsburgh St |
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| 22 Oct 78 | r08        | Kansas City ChiefsKansas City C | 17 - 3 | Cleveland BrownsCleveland Bro |
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| 29 Oct 78 | r09        | Cleveland BrownsCleveland Bro | 41 - 20 | Buffalo BillsBuffalo Bills |
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| 05 Nov 78 | r10        | Tennessee TitansTennessee Tit | 14 - 10 | Cleveland BrownsCleveland Bro |
| 12 Nov 78 | r10        | Cleveland BrownsCleveland Bro | 7 - 19 | Denver BroncosDenver Bronco |
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| 19 Nov 78 | r12        | Indianapolis ColtsIndianapolis | 24 - 45 | Cleveland BrownsCleveland Bro |
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| 26 Nov 78 | r13        | Cleveland BrownsCleveland Bro | 30 - 19 | Los Angeles RamsLos Angeles R |
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| 03 Dec 78 | r14        | Seattle SeahawksSeattle Seaha | 47 - 24 | Cleveland BrownsCleveland Bro |
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| 10 Dec 78 | r15        | Cleveland BrownsCleveland Bro | 37 - 34 | New York JetsNew York Jets |
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| 17 Dec 78 | r16        | Cincinnati BengalsCincinnati Be | 48 - 16 | Cleveland BrownsCleveland Bro |