| 06 Aug 21 | r01        | BournemouthBournemouth | 2 - 2 | West BromWest Brom |
| 07 Aug 21 | r01        | Bristol CityBristol City | 1 - 1 | BlackpoolBlackpool |
| 07 Aug 21 | r01        | QPRQPR | 1 - 1 | MillwallMillwall |
| 07 Aug 21 | r01        | BlackburnBlackburn | 2 - 1 | SwanseaSwansea |
| 07 Aug 21 | r01        | CardiffCardiff | 1 - 1 | BarnsleyBarnsley |
| 07 Aug 21 | r01        | DerbyDerby | 1 - 1 | Huddersfield TownHuddersfield |
| 07 Aug 21 | r01        | LutonLuton | 3 - 0 | PeterboroPeterboro |
| 07 Aug 21 | r01        | PrestonPreston | 1 - 4 | HullHull |
| 07 Aug 21 | r01        | StokeStoke | 3 - 2 | ReadingReading |
| 07 Aug 21 | r01        | Sheffield UnitedSheffield Uni | 0 - 1 | BirminghamBirmingham |
| 08 Aug 21 | r01        | FulhamFulham | 1 - 1 | MiddlesbroughMiddlesbrough |
| 08 Aug 21 | r01        | CoventryCoventry | 2 - 1 | Nottingham F.Nottingham F. |
| |
| 14 Aug 21 | r02        | PeterboroPeterboro | 2 - 1 | DerbyDerby |
| 14 Aug 21 | r02        | BarnsleyBarnsley | 1 - 0 | CoventryCoventry |
| 14 Aug 21 | r02        | BirminghamBirmingham | 0 - 0 | StokeStoke |
| 14 Aug 21 | r02        | BlackpoolBlackpool | 0 - 2 | CardiffCardiff |
| 14 Aug 21 | r02        | Huddersfield TownHuddersfield | 1 - 5 | FulhamFulham |
| 14 Aug 21 | r02        | HullHull | 0 - 3 | QPRQPR |
| 14 Aug 21 | r02        | MiddlesbroughMiddlesbrough | 2 - 1 | Bristol CityBristol City |
| 14 Aug 21 | r02        | MillwallMillwall | 1 - 1 | BlackburnBlackburn |
| 14 Aug 21 | r02        | Nottingham F.Nottingham F. | 1 - 2 | BournemouthBournemouth |
| 14 Aug 21 | r02        | ReadingReading | 2 - 1 | PrestonPreston |
| 14 Aug 21 | r02        | West BromWest Brom | 3 - 2 | LutonLuton |
| 14 Aug 21 | r02        | SwanseaSwansea | 0 - 0 | Sheffield UnitedSheffield Uni |
| |
| 17 Aug 21 | r03        | BarnsleyBarnsley | 0 - 1 | LutonLuton |
| 17 Aug 21 | r03        | BlackpoolBlackpool | 0 - 1 | CoventryCoventry |
| 17 Aug 21 | r03        | Huddersfield TownHuddersfield | 1 - 0 | PrestonPreston |
| 17 Aug 21 | r03        | MillwallMillwall | 1 - 2 | FulhamFulham |
| 17 Aug 21 | r03        | PeterboroPeterboro | 2 - 2 | CardiffCardiff |
| 17 Aug 21 | r03        | SwanseaSwansea | 1 - 3 | StokeStoke |
| 17 Aug 21 | r03        | ReadingReading | 2 - 3 | Bristol CityBristol City |
| 18 Aug 21 | r03        | BirminghamBirmingham | 0 - 2 | BournemouthBournemouth |
| 18 Aug 21 | r03        | HullHull | 0 - 1 | DerbyDerby |
| 18 Aug 21 | r03        | MiddlesbroughMiddlesbrough | 2 - 3 | QPRQPR |
| 18 Aug 21 | r03        | Nottingham F.Nottingham F. | 1 - 2 | BlackburnBlackburn |
| 18 Aug 21 | r03        | West BromWest Brom | 4 - 0 | Sheffield UnitedSheffield Uni |
| |
| 20 Aug 21 | r04        | Bristol CityBristol City | 0 - 1 | SwanseaSwansea |
| 21 Aug 21 | r04        | QPRQPR | 2 - 2 | BarnsleyBarnsley |
| 21 Aug 21 | r04        | BournemouthBournemouth | 2 - 2 | BlackpoolBlackpool |
| 21 Aug 21 | r04        | BlackburnBlackburn | 1 - 2 | West BromWest Brom |
| 21 Aug 21 | r04        | CardiffCardiff | 3 - 1 | MillwallMillwall |
| 21 Aug 21 | r04        | CoventryCoventry | 2 - 1 | ReadingReading |
| 21 Aug 21 | r04        | DerbyDerby | 0 - 0 | MiddlesbroughMiddlesbrough |
| 21 Aug 21 | r04        | FulhamFulham | 2 - 0 | HullHull |
| 21 Aug 21 | r04        | LutonLuton | 0 - 5 | BirminghamBirmingham |
| 21 Aug 21 | r04        | PrestonPreston | 1 - 0 | PeterboroPeterboro |
| 21 Aug 21 | r04        | Sheffield UnitedSheffield Uni | 1 - 2 | Huddersfield TownHuddersfield |
| 21 Aug 21 | r04        | StokeStoke | 1 - 0 | Nottingham F.Nottingham F. |
| |
| 28 Aug 21 | r05        | CardiffCardiff | 1 - 2 | Bristol CityBristol City |
| 28 Aug 21 | r05        | DerbyDerby | 1 - 1 | Nottingham F.Nottingham F. |
| 28 Aug 21 | r05        | QPRQPR | 2 - 0 | CoventryCoventry |
| 28 Aug 21 | r05        | BarnsleyBarnsley | 1 - 1 | BirminghamBirmingham |
| 28 Aug 21 | r05        | FulhamFulham | 3 - 0 | StokeStoke |
| 28 Aug 21 | r05        | Huddersfield TownHuddersfield | 4 - 0 | ReadingReading |
| 28 Aug 21 | r05        | HullHull | 0 - 0 | BournemouthBournemouth |
| 28 Aug 21 | r05        | LutonLuton | 0 - 0 | Sheffield UnitedSheffield Uni |
| 28 Aug 21 | r05        | MiddlesbroughMiddlesbrough | 1 - 1 | BlackburnBlackburn |
| 28 Aug 21 | r05        | MillwallMillwall | 2 - 1 | BlackpoolBlackpool |
| 28 Aug 21 | r05        | PrestonPreston | 3 - 1 | SwanseaSwansea |
| 28 Aug 21 | r05        | PeterboroPeterboro | 0 - 1 | West BromWest Brom |
| |
| 10 Sep 21 | r06        | BirminghamBirmingham | 2 - 0 | DerbyDerby |
| 11 Sep 21 | r06        | Bristol CityBristol City | 0 - 0 | PrestonPreston |
| 11 Sep 21 | r06        | BournemouthBournemouth | 3 - 0 | BarnsleyBarnsley |
| 11 Sep 21 | r06        | BlackburnBlackburn | 2 - 2 | LutonLuton |
| 11 Sep 21 | r06        | BlackpoolBlackpool | 1 - 0 | FulhamFulham |
| 11 Sep 21 | r06        | CoventryCoventry | 2 - 0 | MiddlesbroughMiddlesbrough |
| 11 Sep 21 | r06        | ReadingReading | 3 - 3 | QPRQPR |
| 11 Sep 21 | r06        | Sheffield UnitedSheffield Uni | 6 - 2 | PeterboroPeterboro |
| 11 Sep 21 | r06        | StokeStoke | 2 - 1 | Huddersfield TownHuddersfield |
| 11 Sep 21 | r06        | SwanseaSwansea | 0 - 0 | HullHull |
| 11 Sep 21 | r06        | West BromWest Brom | 1 - 1 | MillwallMillwall |
| 12 Sep 21 | r06        | Nottingham F.Nottingham F. | 1 - 2 | CardiffCardiff |
| |
| 14 Sep 21 | r07        | BournemouthBournemouth | 2 - 1 | QPRQPR |
| 14 Sep 21 | r07        | BlackburnBlackburn | 2 - 0 | HullHull |
| 14 Sep 21 | r07        | BlackpoolBlackpool | 0 - 3 | Huddersfield TownHuddersfield |
| 14 Sep 21 | r07        | Sheffield UnitedSheffield Uni | 2 - 2 | PrestonPreston |
| 14 Sep 21 | r07        | ReadingReading | 3 - 1 | PeterboroPeterboro |
| 14 Sep 21 | r07        | West BromWest Brom | 0 - 0 | DerbyDerby |
| 15 Sep 21 | r07        | Bristol CityBristol City | 1 - 1 | LutonLuton |
| 15 Sep 21 | r07        | BirminghamBirmingham | 1 - 4 | FulhamFulham |
| 15 Sep 21 | r07        | CoventryCoventry | 1 - 0 | CardiffCardiff |
| 15 Sep 21 | r07        | Nottingham F.Nottingham F. | 0 - 2 | MiddlesbroughMiddlesbrough |
| 15 Sep 21 | r07        | SwanseaSwansea | 0 - 0 | MillwallMillwall |
| 15 Sep 21 | r07        | StokeStoke | 1 - 1 | BarnsleyBarnsley |
| |
| 18 Sep 21 | r08        | HullHull | 1 - 3 | Sheffield UnitedSheffield Uni |
| 18 Sep 21 | r08        | QPRQPR | 1 - 2 | Bristol CityBristol City |
| 18 Sep 21 | r08        | BarnsleyBarnsley | 0 - 0 | BlackburnBlackburn |
| 18 Sep 21 | r08        | CardiffCardiff | 0 - 1 | BournemouthBournemouth |
| 18 Sep 21 | r08        | DerbyDerby | 2 - 1 | StokeStoke |
| 18 Sep 21 | r08        | FulhamFulham | 1 - 2 | ReadingReading |
| 18 Sep 21 | r08        | Huddersfield TownHuddersfield | 0 - 2 | Nottingham F.Nottingham F. |
| 18 Sep 21 | r08        | LutonLuton | 3 - 3 | SwanseaSwansea |
| 18 Sep 21 | r08        | MiddlesbroughMiddlesbrough | 1 - 2 | BlackpoolBlackpool |
| 18 Sep 21 | r08        | MillwallMillwall | 1 - 1 | CoventryCoventry |
| 18 Sep 21 | r08        | PeterboroPeterboro | 3 - 0 | BirminghamBirmingham |
| 18 Sep 21 | r08        | PrestonPreston | 1 - 1 | West BromWest Brom |
| |
| 24 Sep 21 | r09        | CoventryCoventry | 3 - 0 | PeterboroPeterboro |
| 24 Sep 21 | r09        | West BromWest Brom | 2 - 1 | QPRQPR |
| 25 Sep 21 | r09        | ReadingReading | 1 - 0 | MiddlesbroughMiddlesbrough |
| 25 Sep 21 | r09        | Bristol CityBristol City | 1 - 1 | FulhamFulham |