| 14 Aug 21 | r01        | ChelseaChelsea | 3 - 0 | Crystal PalaceCrystal Palac |
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| 21 Aug 21 | r02        | Crystal PalaceCrystal Palac | 0 - 0 | BrentfordBrentford |
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| 28 Aug 21 | r03        | West HamWest Ham | 2 - 2 | Crystal PalaceCrystal Palac |
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| 11 Sep 21 | r04        | Crystal PalaceCrystal Palac | 3 - 0 | TottenhamTottenham |
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| 18 Sep 21 | r05        | LiverpoolLiverpool | 3 - 0 | Crystal PalaceCrystal Palac |
| |
| 27 Sep 21 | r06        | Crystal PalaceCrystal Palac | 1 - 1 | BrightonBrighton |
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| 03 Oct 21 | r07        | Crystal PalaceCrystal Palac | 2 - 2 | LeicesterLeicester |
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| 18 Oct 21 | r08        | ArsenalArsenal | 2 - 2 | Crystal PalaceCrystal Palac |
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| 23 Oct 21 | r09        | Crystal PalaceCrystal Palac | 1 - 1 | NewcastleNewcastle |
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| 30 Oct 21 | r10        | Manchester CityManchester Ci | 0 - 2 | Crystal PalaceCrystal Palac |
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| 06 Nov 21 | r11        | Crystal PalaceCrystal Palac | 2 - 0 | WolvesWolves |
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| 20 Nov 21 | r12        | BurnleyBurnley | 3 - 3 | Crystal PalaceCrystal Palac |
| |
| 27 Nov 21 | r13        | Crystal PalaceCrystal Palac | 1 - 2 | Aston VillaAston Villa |
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| 30 Nov 21 | r14        | LeedsLeeds | 1 - 0 | Crystal PalaceCrystal Palac |
| |
| 05 Dec 21 | r15        | Manchester UnitedManchester Un | 1 - 0 | Crystal PalaceCrystal Palac |
| |
| 12 Dec 21 | r16        | Crystal PalaceCrystal Palac | 3 - 1 | EvertonEverton |
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| 15 Dec 21 | r17        | Crystal PalaceCrystal Palac | 2 - 2 | SouthamptonSouthampton |
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| 26 Dec 21 | r19        | TottenhamTottenham | 3 - 0 | Crystal PalaceCrystal Palac |
| |
| 28 Dec 21 | r20        | Crystal PalaceCrystal Palac | 3 - 0 | NorwichNorwich |
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| 01 Jan 22 | r21        | Crystal PalaceCrystal Palac | 2 - 3 | West HamWest Ham |
| |
| 14 Jan 22 | r22        | BrightonBrighton | 1 - 1 | Crystal PalaceCrystal Palac |
| |
| 23 Jan 22 | r23        | Crystal PalaceCrystal Palac | 1 - 3 | LiverpoolLiverpool |
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| 09 Feb 22 | r24        | NorwichNorwich | 1 - 1 | Crystal PalaceCrystal Palac |
| |
| 12 Feb 22 | r25        | BrentfordBrentford | 0 - 0 | Crystal PalaceCrystal Palac |
| |
| 19 Feb 22 | r26        | Crystal PalaceCrystal Palac | 0 - 1 | ChelseaChelsea |
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| 23 Feb 22 | r18        | WatfordWatford | 1 - 4 | Crystal PalaceCrystal Palac |
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| 26 Feb 22 | r27        | Crystal PalaceCrystal Palac | 1 - 1 | BurnleyBurnley |
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| 05 Mar 22 | r28        | WolvesWolves | 0 - 2 | Crystal PalaceCrystal Palac |
| |
| 14 Mar 22 | r29        | Crystal PalaceCrystal Palac | 0 - 0 | Manchester CityManchester Ci |
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| 04 Apr 22 | r31        | Crystal PalaceCrystal Palac | 3 - 0 | ArsenalArsenal |
| |
| 10 Apr 22 | r32        | LeicesterLeicester | 2 - 1 | Crystal PalaceCrystal Palac |
| |
| 20 Apr 22 | r30        | NewcastleNewcastle | 1 - 0 | Crystal PalaceCrystal Palac |
| |
| 25 Apr 22 | r34        | Crystal PalaceCrystal Palac | 0 - 0 | LeedsLeeds |
| |
| 30 Apr 22 | r35        | SouthamptonSouthampton | 1 - 2 | Crystal PalaceCrystal Palac |
| |
| 07 May 22 | r36        | Crystal PalaceCrystal Palac | 1 - 0 | WatfordWatford |
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| 15 May 22 | r37        | Aston VillaAston Villa | 1 - 1 | Crystal PalaceCrystal Palac |
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| 19 May 22 | r33        | EvertonEverton | 3 - 2 | Crystal PalaceCrystal Palac |
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| 22 May 22 | r38        | Crystal PalaceCrystal Palac | 1 - 0 | Manchester UnitedManchester Un |