| 13 Aug 21 | r01        | BrentfordBrentford | 2 - 0 | ArsenalArsenal |
| 14 Aug 21 | r01        | Manchester UnitedManchester Un | 5 - 1 | LeedsLeeds |
| 14 Aug 21 | r01        | BurnleyBurnley | 1 - 2 | BrightonBrighton |
| 14 Aug 21 | r01        | ChelseaChelsea | 3 - 0 | Crystal PalaceCrystal Palac |
| 14 Aug 21 | r01        | EvertonEverton | 3 - 1 | SouthamptonSouthampton |
| 14 Aug 21 | r01        | LeicesterLeicester | 1 - 0 | WolvesWolves |
| 14 Aug 21 | r01        | WatfordWatford | 3 - 2 | Aston VillaAston Villa |
| 14 Aug 21 | r01        | NorwichNorwich | 0 - 3 | LiverpoolLiverpool |
| 15 Aug 21 | r01        | NewcastleNewcastle | 2 - 4 | West HamWest Ham |
| 15 Aug 21 | r01        | TottenhamTottenham | 1 - 0 | Manchester CityManchester Ci |
| |
| 21 Aug 21 | r02        | LiverpoolLiverpool | 2 - 0 | BurnleyBurnley |
| 21 Aug 21 | r02        | Aston VillaAston Villa | 2 - 0 | NewcastleNewcastle |
| 21 Aug 21 | r02        | Crystal PalaceCrystal Palac | 0 - 0 | BrentfordBrentford |
| 21 Aug 21 | r02        | LeedsLeeds | 2 - 2 | EvertonEverton |
| 21 Aug 21 | r02        | Manchester CityManchester Ci | 5 - 0 | NorwichNorwich |
| 21 Aug 21 | r02        | BrightonBrighton | 2 - 0 | WatfordWatford |
| 22 Aug 21 | r02        | SouthamptonSouthampton | 1 - 1 | Manchester UnitedManchester Un |
| 22 Aug 21 | r02        | WolvesWolves | 0 - 1 | TottenhamTottenham |
| 22 Aug 21 | r02        | ArsenalArsenal | 0 - 2 | ChelseaChelsea |
| 23 Aug 21 | r02        | West HamWest Ham | 4 - 1 | LeicesterLeicester |
| |
| 28 Aug 21 | r03        | Manchester CityManchester Ci | 5 - 0 | ArsenalArsenal |
| 28 Aug 21 | r03        | Aston VillaAston Villa | 1 - 1 | BrentfordBrentford |
| 28 Aug 21 | r03        | BrightonBrighton | 0 - 2 | EvertonEverton |
| 28 Aug 21 | r03        | NewcastleNewcastle | 2 - 2 | SouthamptonSouthampton |
| 28 Aug 21 | r03        | NorwichNorwich | 1 - 2 | LeicesterLeicester |
| 28 Aug 21 | r03        | West HamWest Ham | 2 - 2 | Crystal PalaceCrystal Palac |
| 28 Aug 21 | r03        | LiverpoolLiverpool | 1 - 1 | ChelseaChelsea |
| 29 Aug 21 | r03        | BurnleyBurnley | 1 - 1 | LeedsLeeds |
| 29 Aug 21 | r03        | TottenhamTottenham | 1 - 0 | WatfordWatford |
| 29 Aug 21 | r03        | WolvesWolves | 0 - 1 | Manchester UnitedManchester Un |
| |
| 11 Sep 21 | r04        | Crystal PalaceCrystal Palac | 3 - 0 | TottenhamTottenham |
| 11 Sep 21 | r04        | ArsenalArsenal | 1 - 0 | NorwichNorwich |
| 11 Sep 21 | r04        | BrentfordBrentford | 0 - 1 | BrightonBrighton |
| 11 Sep 21 | r04        | LeicesterLeicester | 0 - 1 | Manchester CityManchester Ci |
| 11 Sep 21 | r04        | Manchester UnitedManchester Un | 4 - 1 | NewcastleNewcastle |
| 11 Sep 21 | r04        | SouthamptonSouthampton | 0 - 0 | West HamWest Ham |
| 11 Sep 21 | r04        | WatfordWatford | 0 - 2 | WolvesWolves |
| 11 Sep 21 | r04        | ChelseaChelsea | 3 - 0 | Aston VillaAston Villa |
| 12 Sep 21 | r04        | LeedsLeeds | 0 - 3 | LiverpoolLiverpool |
| 13 Sep 21 | r04        | EvertonEverton | 3 - 1 | BurnleyBurnley |
| |
| 17 Sep 21 | r05        | NewcastleNewcastle | 1 - 1 | LeedsLeeds |
| 18 Sep 21 | r05        | WolvesWolves | 0 - 2 | BrentfordBrentford |
| 18 Sep 21 | r05        | BurnleyBurnley | 0 - 1 | ArsenalArsenal |
| 18 Sep 21 | r05        | LiverpoolLiverpool | 3 - 0 | Crystal PalaceCrystal Palac |
| 18 Sep 21 | r05        | Manchester CityManchester Ci | 0 - 0 | SouthamptonSouthampton |
| 18 Sep 21 | r05        | NorwichNorwich | 1 - 3 | WatfordWatford |
| 18 Sep 21 | r05        | Aston VillaAston Villa | 3 - 0 | EvertonEverton |
| 19 Sep 21 | r05        | BrightonBrighton | 2 - 1 | LeicesterLeicester |
| 19 Sep 21 | r05        | West HamWest Ham | 1 - 2 | Manchester UnitedManchester Un |
| 19 Sep 21 | r05        | TottenhamTottenham | 0 - 3 | ChelseaChelsea |
| |
| 25 Sep 21 | r06        | ChelseaChelsea | 0 - 1 | Manchester CityManchester Ci |
| 25 Sep 21 | r06        | Manchester UnitedManchester Un | 0 - 1 | Aston VillaAston Villa |
| 25 Sep 21 | r06        | EvertonEverton | 2 - 0 | NorwichNorwich |
| 25 Sep 21 | r06        | LeedsLeeds | 1 - 2 | West HamWest Ham |
| 25 Sep 21 | r06        | LeicesterLeicester | 2 - 2 | BurnleyBurnley |
| 25 Sep 21 | r06        | WatfordWatford | 1 - 1 | NewcastleNewcastle |
| 25 Sep 21 | r06        | BrentfordBrentford | 3 - 3 | LiverpoolLiverpool |
| 26 Sep 21 | r06        | SouthamptonSouthampton | 0 - 1 | WolvesWolves |
| 26 Sep 21 | r06        | ArsenalArsenal | 3 - 1 | TottenhamTottenham |
| 27 Sep 21 | r06        | Crystal PalaceCrystal Palac | 1 - 1 | BrightonBrighton |
| |
| 02 Oct 21 | r07        | Manchester UnitedManchester Un | 1 - 1 | EvertonEverton |
| 02 Oct 21 | r07        | BurnleyBurnley | 0 - 0 | NorwichNorwich |
| 02 Oct 21 | r07        | ChelseaChelsea | 3 - 1 | SouthamptonSouthampton |
| 02 Oct 21 | r07        | LeedsLeeds | 1 - 0 | WatfordWatford |
| 02 Oct 21 | r07        | WolvesWolves | 2 - 1 | NewcastleNewcastle |
| 02 Oct 21 | r07        | BrightonBrighton | 0 - 0 | ArsenalArsenal |
| 03 Oct 21 | r07        | Crystal PalaceCrystal Palac | 2 - 2 | LeicesterLeicester |
| 03 Oct 21 | r07        | TottenhamTottenham | 2 - 1 | Aston VillaAston Villa |
| 03 Oct 21 | r07        | West HamWest Ham | 1 - 2 | BrentfordBrentford |
| 03 Oct 21 | r07        | LiverpoolLiverpool | 2 - 2 | Manchester CityManchester Ci |
| |
| 16 Oct 21 | r08        | WatfordWatford | 0 - 5 | LiverpoolLiverpool |
| 16 Oct 21 | r08        | Aston VillaAston Villa | 2 - 3 | WolvesWolves |
| 16 Oct 21 | r08        | LeicesterLeicester | 4 - 2 | Manchester UnitedManchester Un |
| 16 Oct 21 | r08        | Manchester CityManchester Ci | 2 - 0 | BurnleyBurnley |
| 16 Oct 21 | r08        | NorwichNorwich | 0 - 0 | BrightonBrighton |
| 16 Oct 21 | r08        | SouthamptonSouthampton | 1 - 0 | LeedsLeeds |
| 16 Oct 21 | r08        | BrentfordBrentford | 0 - 1 | ChelseaChelsea |
| 17 Oct 21 | r08        | EvertonEverton | 0 - 1 | West HamWest Ham |
| 17 Oct 21 | r08        | NewcastleNewcastle | 2 - 3 | TottenhamTottenham |
| 18 Oct 21 | r08        | ArsenalArsenal | 2 - 2 | Crystal PalaceCrystal Palac |
| |
| 22 Oct 21 | r09        | ArsenalArsenal | 3 - 1 | Aston VillaAston Villa |
| 23 Oct 21 | r09        | ChelseaChelsea | 7 - 0 | NorwichNorwich |
| 23 Oct 21 | r09        | Crystal PalaceCrystal Palac | 1 - 1 | NewcastleNewcastle |
| 23 Oct 21 | r09        | EvertonEverton | 2 - 5 | WatfordWatford |
| 23 Oct 21 | r09        | LeedsLeeds | 1 - 1 | WolvesWolves |
| 23 Oct 21 | r09        | SouthamptonSouthampton | 2 - 2 | BurnleyBurnley |
| 23 Oct 21 | r09        | BrightonBrighton | 1 - 4 | Manchester CityManchester Ci |
| 24 Oct 21 | r09        | BrentfordBrentford | 1 - 2 | LeicesterLeicester |
| 24 Oct 21 | r09        | West HamWest Ham | 1 - 0 | TottenhamTottenham |
| 24 Oct 21 | r09        | Manchester UnitedManchester Un | 0 - 5 | LiverpoolLiverpool |
| |
| 30 Oct 21 | r10        | LeicesterLeicester | 0 - 2 | ArsenalArsenal |
| 30 Oct 21 | r10        | BurnleyBurnley | 3 - 1 | BrentfordBrentford |
| 30 Oct 21 | r10        | LiverpoolLiverpool | 2 - 2 | BrightonBrighton |
| 30 Oct 21 | r10        | Manchester CityManchester Ci | 0 - 2 | Crystal PalaceCrystal Palac |
| 30 Oct 21 | r10        | NewcastleNewcastle | 0 - 3 | ChelseaChelsea |
| 30 Oct 21 | r10        | WatfordWatford | 0 - 1 | SouthamptonSouthampton |
| 30 Oct 21 | r10        | TottenhamTottenham | 0 - 3 | Manchester UnitedManchester Un |
| 31 Oct 21 | r10        | NorwichNorwich | 1 - 2 | LeedsLeeds |
| 31 Oct 21 | r10        | Aston VillaAston Villa | 1 - 4 | West HamWest Ham |
| 01 Nov 21 | r10        | WolvesWolves | 2 - 1 | EvertonEverton |