| 15 Aug 21 | r01        | TottenhamTottenham | 1 - 0 | Manchester CityManchester Ci |
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| 21 Aug 21 | r02        | Manchester CityManchester Ci | 5 - 0 | NorwichNorwich |
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| 28 Aug 21 | r03        | Manchester CityManchester Ci | 5 - 0 | ArsenalArsenal |
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| 11 Sep 21 | r04        | LeicesterLeicester | 0 - 1 | Manchester CityManchester Ci |
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| 18 Sep 21 | r05        | Manchester CityManchester Ci | 0 - 0 | SouthamptonSouthampton |
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| 25 Sep 21 | r06        | ChelseaChelsea | 0 - 1 | Manchester CityManchester Ci |
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| 03 Oct 21 | r07        | LiverpoolLiverpool | 2 - 2 | Manchester CityManchester Ci |
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| 16 Oct 21 | r08        | Manchester CityManchester Ci | 2 - 0 | BurnleyBurnley |
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| 23 Oct 21 | r09        | BrightonBrighton | 1 - 4 | Manchester CityManchester Ci |
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| 30 Oct 21 | r10        | Manchester CityManchester Ci | 0 - 2 | Crystal PalaceCrystal Palac |
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| 06 Nov 21 | r11        | Manchester UnitedManchester Un | 0 - 2 | Manchester CityManchester Ci |
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| 21 Nov 21 | r12        | Manchester CityManchester Ci | 3 - 0 | EvertonEverton |
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| 28 Nov 21 | r13        | Manchester CityManchester Ci | 2 - 1 | West HamWest Ham |
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| 01 Dec 21 | r14        | Aston VillaAston Villa | 1 - 2 | Manchester CityManchester Ci |
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| 04 Dec 21 | r15        | WatfordWatford | 1 - 3 | Manchester CityManchester Ci |
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| 11 Dec 21 | r16        | Manchester CityManchester Ci | 1 - 0 | WolvesWolves |
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| 14 Dec 21 | r17        | Manchester CityManchester Ci | 7 - 0 | LeedsLeeds |
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| 19 Dec 21 | r18        | NewcastleNewcastle | 0 - 4 | Manchester CityManchester Ci |
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| 26 Dec 21 | r19        | Manchester CityManchester Ci | 6 - 3 | LeicesterLeicester |
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| 29 Dec 21 | r20        | BrentfordBrentford | 0 - 1 | Manchester CityManchester Ci |
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| 01 Jan 22 | r21        | ArsenalArsenal | 1 - 2 | Manchester CityManchester Ci |
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| 15 Jan 22 | r22        | Manchester CityManchester Ci | 1 - 0 | ChelseaChelsea |
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| 22 Jan 22 | r23        | SouthamptonSouthampton | 1 - 1 | Manchester CityManchester Ci |
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| 09 Feb 22 | r24        | Manchester CityManchester Ci | 2 - 0 | BrentfordBrentford |
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| 12 Feb 22 | r25        | NorwichNorwich | 0 - 4 | Manchester CityManchester Ci |
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| 19 Feb 22 | r26        | Manchester CityManchester Ci | 2 - 3 | TottenhamTottenham |
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| 26 Feb 22 | r27        | EvertonEverton | 0 - 1 | Manchester CityManchester Ci |
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| 06 Mar 22 | r28        | Manchester CityManchester Ci | 4 - 1 | Manchester UnitedManchester Un |
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| 14 Mar 22 | r29        | Crystal PalaceCrystal Palac | 0 - 0 | Manchester CityManchester Ci |
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| 02 Apr 22 | r31        | BurnleyBurnley | 0 - 2 | Manchester CityManchester Ci |
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| 10 Apr 22 | r32        | Manchester CityManchester Ci | 2 - 2 | LiverpoolLiverpool |
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| 20 Apr 22 | r30        | Manchester CityManchester Ci | 3 - 0 | BrightonBrighton |
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| 23 Apr 22 | r34        | Manchester CityManchester Ci | 5 - 1 | WatfordWatford |
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| 30 Apr 22 | r35        | LeedsLeeds | 0 - 4 | Manchester CityManchester Ci |
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| 08 May 22 | r36        | Manchester CityManchester Ci | 5 - 0 | NewcastleNewcastle |
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| 11 May 22 | r33        | WolvesWolves | 1 - 5 | Manchester CityManchester Ci |
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| 15 May 22 | r37        | West HamWest Ham | 2 - 2 | Manchester CityManchester Ci |
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| 22 May 22 | r38        | Manchester CityManchester Ci | 3 - 2 | Aston VillaAston Villa |