| 14 Aug 21 | r01        | Manchester UnitedManchester Un | 5 - 1 | LeedsLeeds |
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| 22 Aug 21 | r02        | SouthamptonSouthampton | 1 - 1 | Manchester UnitedManchester Un |
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| 29 Aug 21 | r03        | WolvesWolves | 0 - 1 | Manchester UnitedManchester Un |
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| 11 Sep 21 | r04        | Manchester UnitedManchester Un | 4 - 1 | NewcastleNewcastle |
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| 19 Sep 21 | r05        | West HamWest Ham | 1 - 2 | Manchester UnitedManchester Un |
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| 25 Sep 21 | r06        | Manchester UnitedManchester Un | 0 - 1 | Aston VillaAston Villa |
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| 02 Oct 21 | r07        | Manchester UnitedManchester Un | 1 - 1 | EvertonEverton |
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| 16 Oct 21 | r08        | LeicesterLeicester | 4 - 2 | Manchester UnitedManchester Un |
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| 24 Oct 21 | r09        | Manchester UnitedManchester Un | 0 - 5 | LiverpoolLiverpool |
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| 30 Oct 21 | r10        | TottenhamTottenham | 0 - 3 | Manchester UnitedManchester Un |
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| 06 Nov 21 | r11        | Manchester UnitedManchester Un | 0 - 2 | Manchester CityManchester Ci |
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| 20 Nov 21 | r12        | WatfordWatford | 4 - 1 | Manchester UnitedManchester Un |
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| 28 Nov 21 | r13        | ChelseaChelsea | 1 - 1 | Manchester UnitedManchester Un |
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| 02 Dec 21 | r14        | Manchester UnitedManchester Un | 3 - 2 | ArsenalArsenal |
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| 05 Dec 21 | r15        | Manchester UnitedManchester Un | 1 - 0 | Crystal PalaceCrystal Palac |
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| 11 Dec 21 | r16        | NorwichNorwich | 0 - 1 | Manchester UnitedManchester Un |
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| 27 Dec 21 | r19        | NewcastleNewcastle | 1 - 1 | Manchester UnitedManchester Un |
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| 30 Dec 21 | r20        | Manchester UnitedManchester Un | 3 - 1 | BurnleyBurnley |
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| 03 Jan 22 | r21        | Manchester UnitedManchester Un | 0 - 1 | WolvesWolves |
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| 15 Jan 22 | r22        | Aston VillaAston Villa | 2 - 2 | Manchester UnitedManchester Un |
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| 19 Jan 22 | r17        | BrentfordBrentford | 1 - 3 | Manchester UnitedManchester Un |
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| 22 Jan 22 | r23        | Manchester UnitedManchester Un | 1 - 0 | West HamWest Ham |
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| 08 Feb 22 | r24        | BurnleyBurnley | 1 - 1 | Manchester UnitedManchester Un |
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| 12 Feb 22 | r25        | Manchester UnitedManchester Un | 1 - 1 | SouthamptonSouthampton |
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| 15 Feb 22 | r18        | Manchester UnitedManchester Un | 2 - 0 | BrightonBrighton |
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| 20 Feb 22 | r26        | LeedsLeeds | 2 - 4 | Manchester UnitedManchester Un |
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| 26 Feb 22 | r27        | Manchester UnitedManchester Un | 0 - 0 | WatfordWatford |
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| 06 Mar 22 | r28        | Manchester CityManchester Ci | 4 - 1 | Manchester UnitedManchester Un |
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| 12 Mar 22 | r29        | Manchester UnitedManchester Un | 3 - 2 | TottenhamTottenham |
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| 02 Apr 22 | r31        | Manchester UnitedManchester Un | 1 - 1 | LeicesterLeicester |
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| 09 Apr 22 | r32        | EvertonEverton | 1 - 0 | Manchester UnitedManchester Un |
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| 16 Apr 22 | r33        | Manchester UnitedManchester Un | 3 - 2 | NorwichNorwich |
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| 19 Apr 22 | r30        | LiverpoolLiverpool | 4 - 0 | Manchester UnitedManchester Un |
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| 23 Apr 22 | r34        | ArsenalArsenal | 3 - 1 | Manchester UnitedManchester Un |
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| 28 Apr 22 | r37        | Manchester UnitedManchester Un | 1 - 1 | ChelseaChelsea |
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| 02 May 22 | r35        | Manchester UnitedManchester Un | 3 - 0 | BrentfordBrentford |
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| 07 May 22 | r36        | BrightonBrighton | 4 - 0 | Manchester UnitedManchester Un |
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| 22 May 22 | r38        | Crystal PalaceCrystal Palac | 1 - 0 | Manchester UnitedManchester Un |